Gabrr1 - gamma-aminobutyric acid (GABA) C receptor, subunit rho 1 Gene

Mus musculus

Also known as GABA-C

Gene ID: 14408 | Gene type: protein coding

About Gabrr1

Summary

Enables ligand-gated ion channel activity involved in regulation of presynaptic membrane potential and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to act upstream of or within chloride transport. Located in glutamatergic synapse. Is active in GABA-ergic synapse. Is expressed in brain; cerebral cortex; and retina. Orthologous to human GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1). [provided by Alliance of Genome Resources, Apr 2022]

Gabrr1 Products(1)

mRNA	Protein	Name
NM_008075.2	NP_032101.3	gamma-aminobutyric acid receptor subunit rho-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	EXP EXP: Inferred from Experiment	23583111	MGI
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	23583111	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	30902970	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	12019334	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	12019334	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	12019334	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	12019334	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	12019334	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	12019334	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12019334	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	12019334	MGI
is active in intracellular vesicle	IDA IDA: Inferred from direct assay	30902970	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	25422464	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	23583111	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gamma-aminobutyric acid receptor subunit rho-1

GABA(A) receptor subunit rho-1	GABA(C) receptor
gamma-aminobutyric acid (GABA-A) receptor, subunit rho 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05225	GABRR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gabrr1	NCBI	NCBI:2569

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