Gas1 - growth arrest specific 1 Gene

Also Known as Gas-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14451

Summary

Involved in several processes, including negative regulation of cell growth; odontogenesis; and regulation of smoothened signaling pathway. Acts upstream of or within several processes, including nervous system development; regulation of smoothened signaling pathway; and sensory organ development. Located in plasma membrane. Is anchored component of plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human GAS1 (growth arrest specific 1). [provided by Alliance of Genome Resources, Apr 2022]

Gas1 Products (1)

mRNA Protein Name
NM_008086.3 NP_032112.1 growth arrest-specific protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables oxysterol binding IMP
IMP: Inferred from mutant phenotype
34799735 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11572986 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
11456442 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
17504941 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
17525797 MGI
acts upstream of or within cell fate commitment IGI
IGI: Inferred from genetic interaction
17504941 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
11456441 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11456442 MGI
acts upstream of or within cerebellum morphogenesis IMP
IMP: Inferred from mutant phenotype
11456442 MGI
acts upstream of or within developmental growth IMP
IMP: Inferred from mutant phenotype
11456442 MGI
acts upstream of or within dorsal/ventral neural tube patterning IGI
IGI: Inferred from genetic interaction
17504941 MGI
acts upstream of or within dorsal/ventral neural tube patterning IMP
IMP: Inferred from mutant phenotype
17504940 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
17504940 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IGI
IGI: Inferred from genetic interaction
17525797 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: Inferred from mutant phenotype
17525797 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
17504940 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
17504940 MGI
acts upstream of or within embryonic morphogenesis IGI
IGI: Inferred from genetic interaction
17504941 MGI
acts upstream of or within embryonic morphogenesis IMP
IMP: Inferred from mutant phenotype
17504941 MGI
acts upstream of or within embryonic skeletal system development IGI
IGI: Inferred from genetic interaction
17504941 MGI
acts upstream of or within embryonic skeletal system development IMP
IMP: Inferred from mutant phenotype
17504941 MGI
acts upstream of or within eye morphogenesis IMP
IMP: Inferred from mutant phenotype
11456441 MGI
acts upstream of or within middle ear morphogenesis IMP
IMP: Inferred from mutant phenotype
17525797 MGI
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
15070677 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11456442 MGI
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
10996316 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
11456441 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: Inferred from direct assay
15070677 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IDA
IDA: Inferred from direct assay
11572986 MGI
involved in odontogenesis IMP
IMP: Inferred from mutant phenotype
19211681 MGI
acts upstream of or within outer ear morphogenesis IMP
IMP: Inferred from mutant phenotype
17525797 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11456442 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17525797 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
17525797 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IDA
IDA: Inferred from direct assay
17504940 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
17504940 MGI
acts upstream of or within programmed cell death IDA
IDA: Inferred from direct assay
11906213 MGI
involved in regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
19478089 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
17525797 MGI
acts upstream of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
17504940 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
11906213 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10996315 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth arrest-specific protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107199 N-Butylthiophosphoric triamide Inhibitor 99.76% Unkown
HY-RS05281 GAS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W016613 Tri(ethylene glycol) monoethyl ether / Unkown
HY-RS22178 Gas1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28700 Gas1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gas1 NCBI NCBI:2619