Gbp2 - guanylate binding protein 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14469

Summary

Predicted to enable several functions, including HSP90 protein binding activity; cytoskeletal protein binding activity; and guanyl ribonucleotide binding activity. Acts upstream of or within several processes, including cellular response to interferon-beta; cellular response to lipopolysaccharide; and defense response to Other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to several human genes including GBP2 (guanylate binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Gbp2 Products (1)

mRNA Protein Name
NM_010260.1 NP_034390.1 guanylate-binding protein 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in activation of innate immune response IMP
IMP: Inferred from mutant phenotype
24739961 MGI
acts upstream of or within adhesion of symbiont to host IDA
IDA: Inferred from direct assay
18025219 MGI
acts upstream of or within cellular response to interferon-beta IDA
IDA: Inferred from direct assay
19158679 MGI
involved in cellular response to interferon-beta IDA
IDA: Inferred from direct assay
18025219 MGI
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
18025219 MGI
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
24715728 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
18025219 MGI
involved in cytolysis in another organism IDA
IDA: Inferred from direct assay
25774715 MGI
involved in cytolysis in another organism IMP
IMP: Inferred from mutant phenotype
24715728 MGI
acts upstream of or within defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
18025219 MGI
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
25774715 MGI
involved in defense response to bacterium IMP
IMP: Inferred from mutant phenotype
24715728 MGI
acts upstream of or within defense response to protozoan IDA
IDA: Inferred from direct assay
18025219 MGI
involved in positive regulation of AIM2 inflammasome complex assembly IDA
IDA: Inferred from direct assay
25774715 MGI
involved in positive regulation of pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
25774715 MGI
involved in positive regulation of pyroptotic inflammatory response IMP
IMP: Inferred from mutant phenotype
24715728 MGI
involved in protein targeting IDA
IDA: Inferred from direct assay
27693356 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
18025219 MGI
is active in symbiont cell surface IDA
IDA: Inferred from direct assay
27693356 MGI
located in symbiont-containing vacuole membrane IDA
IDA: Inferred from direct assay
18025219 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanylate-binding protein 2

  • GBP-2

  • GTP-binding protein 2

  • guanine nucleotide-binding protein 2

  • guanylate nucleotide binding protein 2

  • guanylate-binding protein 1

  • interferon-induced guanylate-binding protein 2

  • mGBP-2

  • mGBP2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05308 GBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17953 Gbp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24424 Gbp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gbp2 NCBI NCBI:2634