ISM2 - isthmin 2 Gene

Also Known as TAIL1; THSD3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 145501

About ISM2

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:77,474,394-77,498,816 (from NCBI)

This gene has 8 transcripts (splice variants) and 56 orthologues. Restricted expression toward placenta (RPKM 113.4).

Summary

The protein encoded by this gene contains a type 1 thrombospondin domain, which is present in thrombospondin, a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Mar 2009]

ISM2 Products (2)

mRNA	Protein	Name
NM_182509.4	NP_872315.2	isthmin-2 isoform 3 precursor
NM_199296.3	NP_954993.1	isthmin-2 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ISM2 Protein Structure

TSP_1

AMOP

0
100
200
300
400
500
571 a.a.

Protein Preferred Names	Protein Names
isthmin-2	isthmin 2 homolog

ISM2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ISM2	Q6H9L7	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	ISM2	Q6H9L7	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	ISM2	Q6H9L7	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Indolent Systemic Mastocytosis	Ism
Placental Site Trophoblastic Tumor	Trophoblastic Tumor Placental Site Trophoblastic Tumor, Placental Site Placental Site Trophoblastic Tumour Placental-Site Gestational Trophoblastic Neoplasm Placenta Neoplasm Psst Deciduoma Placental Cancer Primary Malignant Neoplasm Of Placenta
Arrhythmogenic Right Ventricular Dysplasia, Familial, 9	Arrhythmogenic Right Ventricular Dysplasia 9 ARVD9 Arrhythmogenic Right Ventricular Cardiomyopathy 9 Arvc9 Familial Arrhythmogenic Right Ventricular Dysplasia 9 Dysplasia, Arrhythmogenic Right Ventricular, Type 9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06936	ISM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ISM2	VGNC	VGNC:73642
Felis catus	ISM2	VGNC	VGNC:62977
Mus musculus	ISM2	MGD	MGI:2685110
Rattus norvegicus	ISM2	RGD	RGD:1589343
Bos taurus	ISM2	VGNC	VGNC:55117
Others	ISM2	NCBI