Gfra4 - glial cell line derived neurotrophic factor family receptor alpha 4 Gene

Also Known as G630015H18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14588

Summary

This gene encodes a transmembrane protein that functions as the receptor for persephin, a member of the glial cell line derived Neurotrophic Factors. The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the receptor tyrosine kinase RET. A complete lack of the encoded protein impairs production of thyroid Calcitonin and increases the rate of bone formation in young mice. [provided by RefSeq, Jul 2016]

Gfra4 Products (6)

mRNA Protein Name
NM_001136063.2 NP_001129535.1 GDNF family receptor alpha-4 isoform 1 precursor
NM_001271001.1 NP_001257930.1 GDNF family receptor alpha-4 isoform 3 preproprotein
NM_001271002.1 NP_001257931.1 GDNF family receptor alpha-4 isoform 4
NM_001407238.1 NP_001394167.1 GDNF family receptor alpha-4 isoform 5
NM_001407239.1 NP_001394168.1 GDNF family receptor alpha-4 isoform 6
NM_020014.2 NP_064398.1 GDNF family receptor alpha-4 isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
16497798 MGI
acts upstream of ossification IMP
IMP: Inferred from mutant phenotype
16497798 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GDNF family receptor alpha-4

  • GDNFR-alpha-4

  • GFR alpha-4

  • persephin receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05389 GFRA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992009 Anti-GFRA4 Antibody Inhibitor / Unkown
HY-P992232 Anti-GFRA4 Antibody (scFv) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gfra4 NCBI NCBI:64096