Gja3 - gap junction protein, alpha 3 Gene

Also Known as Cx43; Cx46; Cnx46; Cxnj1; Gja-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14611

Summary

Predicted to enable gap junction hemi-channel activity and identical protein binding activity. Predicted to be involved in several processes, including gap junction-mediated intercellular transport; response to hydrogen peroxide; and response to pH. Located in gap junction and plasma membrane. Is expressed in lens; metanephros; and testis. Used to study cataract 14 multiple types. Human ortholog(s) of this gene implicated in cataract 14 multiple types. Orthologous to human GJA3 (Gap Junction Protein alpha 3). [provided by Alliance of Genome Resources, Apr 2022]

Gja3 Products (2)

mRNA Protein Name
NM_001271623.1 NP_001258552.1 gap junction alpha-3 protein precursor
NM_016975.3 NP_058671.2 gap junction alpha-3 protein precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in gap junction IDA
IDA: Inferred from direct assay
11786642 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9620080 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gap junction alpha-3 protein

  • alpha 3 connexin

  • connexin j1

  • connexin-46

  • gap junction membrane channel protein alpha 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05442 GJA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gja3 NCBI NCBI:2700