2. Gene
  3. Gja8 - gap junction protein, alpha 8 Gene

Gja8 - gap junction protein, alpha 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as dcm; Aey5; Cx50; Cxnl; Cnx50; Lop10

Gene ID: 14616 | Gene type: protein coding

About Gja8

Summary

Predicted to enable gap junction channel activity and identical protein binding activity. Acts upstream of or within lens development in camera-type eye. Located in plasma membrane. Is expressed in embryo; eye; head; lens; and testis. Used to study cataract 1 multiple types. Human ortholog(s) of this gene implicated in cataract and cataract 1 multiple types. Orthologous to human GJA8 (Gap Junction Protein alpha 8). [provided by Alliance of Genome Resources, Apr 2022]

Gja8 Products(1)

mRNA Protein Name
NM_008123.3 NP_032149.1 gap junction alpha-8 protein
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
11782410 MGI
acts upstream of or within lens development in camera-type eye IMP
IMP: Inferred from mutant phenotype
6877261 MGI
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
9620080 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gap junction alpha-8 protein

alpha 8 connexin

connexin l

connexin-50

gap junction membrane channel protein alpha 8

lens fiber protein MP70

lens opacity 10

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05445 GJA8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gja8 NCBI NCBI:2703