Gli2 - GLI-Kruppel family member GLI2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14633

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and regulation of smoothened signaling pathway. Located in several cellular components, including axoneme; ciliary tip; and nuclear speck. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Human ortholog(s) of this gene implicated in Culler-Jones syndrome; holoprosencephaly 9; and spina bifida. Orthologous to human GLI2 (Gli family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Gli2 Products (1)

mRNA Protein Name
NM_001081125.1 NP_001074594.1 zinc finger protein GLI2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16880529 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16880529 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15614767 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
23201751 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16396903 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
25808752 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11238441 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16611981 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
19124651 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anatomical structure development IGI
IGI: Inferred from genetic interaction
11485934 MGI
acts upstream of or within anatomical structure development IMP
IMP: Inferred from mutant phenotype
11485934 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IGI
IGI: Inferred from genetic interaction
9731531 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
22841643 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
10409510 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IMP
IMP: Inferred from mutant phenotype
9731531 MGI
acts upstream of or within cell differentiation IMP
IMP: Inferred from mutant phenotype
9636069 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
15496441 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9731531 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
19103752 MGI
acts upstream of or within cerebellar cortex morphogenesis IGI
IGI: Inferred from genetic interaction
16571625 MGI
acts upstream of or within cerebellar cortex morphogenesis IMP
IMP: Inferred from mutant phenotype
16571625 MGI
acts upstream of or within chondrocyte differentiation IGI
IGI: Inferred from genetic interaction
23333501 MGI
acts upstream of or within cochlea morphogenesis IMP
IMP: Inferred from mutant phenotype
17395647 MGI
acts upstream of or within developmental growth IMP
IMP: Inferred from mutant phenotype
16571630 MGI
acts upstream of or within dorsal/ventral neural tube patterning IDA
IDA: Inferred from direct assay
9247260 MGI
acts upstream of or within dorsal/ventral neural tube patterning IMP
IMP: Inferred from mutant phenotype
18590716 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: Inferred from genetic interaction
16342201 MGI
acts upstream of or within embryonic digestive tract development IMP
IMP: Inferred from mutant phenotype
10693670 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
19056373 MGI
acts upstream of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
16054035 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
9731531 MGI
acts upstream of or within floor plate formation IMP
IMP: Inferred from mutant phenotype
9636069 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
23201751 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
29659575 MGI
acts upstream of or within head development IMP
IMP: Inferred from mutant phenotype
19056373 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
11172440 MGI
acts upstream of or within hindbrain development IGI
IGI: Inferred from genetic interaction
15496441 MGI
acts upstream of or within hindbrain development IMP
IMP: Inferred from mutant phenotype
8575294 MGI
acts upstream of or within hindgut morphogenesis IGI
IGI: Inferred from genetic interaction
11485934 MGI
acts upstream of or within hindgut morphogenesis IMP
IMP: Inferred from mutant phenotype
11485934 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
19056373 MGI
acts upstream of or within kidney development IGI
IGI: Inferred from genetic interaction
11172440 MGI
acts upstream of or within lung development IGI
IGI: Inferred from genetic interaction
10725236 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
9731531 MGI
acts upstream of or within mammary gland development IMP
IMP: Inferred from mutant phenotype
11783999 MGI
acts upstream of or within mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
11783999 MGI
acts upstream of or within morphogenesis of an epithelium IMP
IMP: Inferred from mutant phenotype
16707121 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
19056373 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17328886 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
28778798 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16611981 MGI
acts upstream of or within neural tube development IMP
IMP: Inferred from mutant phenotype
19056373 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
16267219 MGI
acts upstream of neuron differentiation IGI
IGI: Inferred from genetic interaction
16950124 MGI
acts upstream of or within notochord regression IGI
IGI: Inferred from genetic interaction
10725236 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
9655803 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
9655803 MGI
acts upstream of or within osteoblast development IDA
IDA: Inferred from direct assay
16880529 MGI
acts upstream of or within osteoblast development IMP
IMP: Inferred from mutant phenotype
16880529 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: Inferred from genetic interaction
22771375 MGI
acts upstream of or within pattern specification process IGI
IGI: Inferred from genetic interaction
14602680 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
8575294 MGI
acts upstream of or within pituitary gland development IGI
IGI: Inferred from genetic interaction
10725236 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15614767 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16254602 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18590716 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17035233 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
15496441 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15496441 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
16054035 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
9731531 MGI
acts upstream of or within positive regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
16950124 MGI
acts upstream of or within positive regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
9731531 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16880529 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16880529 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16880529 MGI
acts upstream of or within prostatic bud formation IMP
IMP: Inferred from mutant phenotype
16707121 MGI
acts upstream of or within proximal/distal pattern formation IGI
IGI: Inferred from genetic interaction
16342201 MGI
acts upstream of or within regulation of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
28817564 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
9006072 MGI
acts upstream of or within smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
16571625 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
16571625 MGI
acts upstream of or within smoothened signaling pathway involved in dorsal/ventral neural tube patterning IGI
IGI: Inferred from genetic interaction
17395647 MGI
acts upstream of or within smoothened signaling pathway involved in spinal cord motor neuron cell fate specification IGI
IGI: Inferred from genetic interaction
15215207 MGI
acts upstream of or within smoothened signaling pathway involved in ventral spinal cord interneuron specification IGI
IGI: Inferred from genetic interaction
15215207 MGI
acts upstream of or within spinal cord dorsal/ventral patterning IGI
IGI: Inferred from genetic interaction
15215207 MGI
acts upstream of or within spinal cord dorsal/ventral patterning IMP
IMP: Inferred from mutant phenotype
11748151 MGI
acts upstream of or within spinal cord motor neuron differentiation IMP
IMP: Inferred from mutant phenotype
21552265 MGI
acts upstream of or within spinal cord ventral commissure morphogenesis IMP
IMP: Inferred from mutant phenotype
10409510 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
9731531 MGI
acts upstream of or within tube development IGI
IGI: Inferred from genetic interaction
9731531 MGI
acts upstream of or within ventral midline development IGI
IGI: Inferred from genetic interaction
10725236 MGI
acts upstream of or within ventral midline development IMP
IMP: Inferred from mutant phenotype
10725236 MGI
acts upstream of or within ventral spinal cord development IMP
IMP: Inferred from mutant phenotype
11748151 MGI
Cellular Component GO Annotation Evidence References Source
located in axoneme IDA
IDA: Inferred from direct assay
21209331 MGI
located in ciliary tip IDA
IDA: Inferred from direct assay
21653639 MGI
located in cilium IDA
IDA: Inferred from direct assay
16254602 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
19286674 MGI
located in cytoplasm IGI
IGI: Inferred from genetic interaction
16316410 MGI
located in membrane IDA
IDA: Inferred from direct assay
19286674 MGI
located in motile cilium IDA
IDA: Inferred from direct assay
18590716 MGI
located in nuclear speck IDA
IDA: Inferred from direct assay
19684112 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11238441 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein GLI2

  • Tax helper protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13901 GANT 61 99.80% Unkown
HY-RS05475 GLI2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-12487 NL-103 Inhibitor / Unkown
HY-137567 Prostaglandin E1 ethanolamide Activator / Unkown
HY-183335 SMO-IN-6 / Unkown
HY-RS05481 GLIS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13901R GANT 61 (Standard) / Unkown
HY-RS20743 Gli2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21582 Glis2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27255 Gli2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28100 Glis2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gli2 NCBI NCBI:2736