SLFN13 - schlafen family member 13 Gene

Also Known as SLFN10; hSLFN13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 146857

About SLFN13

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,435,096-35,449,766 (from NCBI)

This gene has 11 transcripts (splice variants), 110 orthologues and 6 paralogues. Broad expression in bone marrow (RPKM 5.2), spleen (RPKM 4.2) and 24 other tissues.

Summary

Enables endoribonuclease activity. Involved in rRNA catabolic process and tRNA catabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SLFN13 Products (1)

mRNA Protein Name
NM_144682.6 NP_653283.3 schlafen family member 13

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA endonuclease activity IDA
IDA: Inferred from direct assay
29563550 GOA
Biological Process GO Annotation Evidence References Source
involved in rRNA catabolic process IDA
IDA: Inferred from direct assay
29563550 GOA
involved in tRNA decay IDA
IDA: Inferred from direct assay
29563550 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
29563550 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLFN13 Protein Structure

AlbA_2

AlbA_2: Putative DNA-binding domain (208 - 334)

DUF2075

DUF2075: Uncharacterized conserved protein (DUF2075) (595 - 709)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 897 a.a.
Protein Preferred Names Protein Names

schlafen family member 13

  • schlafen-13

Related Diseases

Diseases Alias
Bleeding Disorder, Platelet-Type, 20

  • Platelet-Type Bleeding Disorder 20

  • BDPLT20

  • Autosomal Dominant Thrombocytopenia With Platelet Secretion Defect
Monkeypox

  • Monkeypox Virus Infections
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13366 SLFN13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown