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KCTD11 - potassium channel tetramerization domain containing 11 Gene

Also Known as REN; KCASH1; C17orf36; REN/KCTD11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 147040

About KCTD11

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,352,162-7,354,944 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 96 orthologues and 13 paralogues.

Summary

Enables identical protein binding activity. Predicted to be involved in positive regulation of neuron differentiation. Predicted to act upstream of or within negative regulation of neuroblast proliferation and negative regulation of smoothened signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

KCTD11 Products (2)

mRNA	Protein	Name
NM_001002914.3	NP_001002914.1	BTB/POZ domain-containing protein KCTD11 s
NM_001363642.1	NP_001350571.1	BTB/POZ domain-containing protein KCTD11 l

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	27152988	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCTD11 Protein Structure

BTB_2

0
100
200
232 a.a.

Protein Preferred Names	Protein Names
BTB/POZ domain-containing protein KCTD11	RING-type E3 ubiquitin transferase subunit KCTD11

KCTD11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KCTD11	Q693B1	KCTD11	Homo sapiens	Q693B1	GMS	27152988
Intra	KCTD11	Q693B1	KCTD11	Homo sapiens	Q693B1	EM	27152988

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Scalp-Ear-Nipple Syndrome	Finlay-Marks Syndrome Sen Syndrome SENS Scalp Ear Nipple Syndrome Hereditary Syndrome Of Lumpy Scalp, Odd Ears And Rudimentary Nipples Hereditary Syndrome Of Lumpy Scalp, Odd Ears, And Rudimentary Nipples Indian Childhood Cirrhosis
Progressive Myoclonus Epilepsy	Pme Progressive Myoclonic Epilepsy Myoclonic Epilepsies, Progressive Unverricht-Lundborg Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07188	KCTD11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KCTD11	MGD	MGI:2448712
Macaca mulatta	KCTD11	VGNC	VGNC:99161
Rattus norvegicus	KCTD11	RGD	RGD:1307125
Bos taurus	KCTD11	VGNC	VGNC:30501
Others	KCTD11	NCBI