Gnrh1 - gonadotropin releasing hormone 1 Gene

Also Known as hpg; Gnrh; LHRH; Lnrh; Gnrh2; Lhrh1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14714

Summary

This gene encodes hypophysiotropic peptides belonging to the family of gonadotropin-releasing Hormones that stimulate the release of gonadotropins and suppress secretion of Prolactin from the pituitary gland. The encoded protein is proteolytically processed to generate two biologically active mature peptides. A deletional mutation encompassing the distal half of this gene in mice resulting in the loss of the encoded protein leads to hypogonadism and infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Gnrh1 Products (1)

mRNA Protein Name
NM_008145.3 NP_032171.1 progonadoliberin-1 preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of neuron migration IDA
IDA: Inferred from direct assay
23321696 MGI
acts upstream of or within negative regulation of neuron migration IGI
IGI: Inferred from genetic interaction
23321696 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17332066 MGI
acts upstream of or within regulation of ovarian follicle development IMP
IMP: Inferred from mutant phenotype
10803590 MGI
acts upstream of or within response to ethanol IDA
IDA: Inferred from direct assay
7771642 MGI
acts upstream of or within response to steroid hormone IMP
IMP: Inferred from mutant phenotype
17332066 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
37189369 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

progonadoliberin-1

  • gonadotropin releasing hormone 2

  • luteinizing hormone-releasing hormone I

  • progonadoliberin I

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05576 GNRH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnrh1 NCBI NCBI:2796