2. Gene
  3. Gria1 - glutamate receptor, ionotropic, AMPA1 (alpha 1) Gene

Gria1 - glutamate receptor, ionotropic, AMPA1 (alpha 1) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Glr1; Glr-1; GluA1; GluRA; Glur1; HIPA1; GluR-A; Glur-1; gluR-K1; 2900051M01Rik

Gene ID: 14799 | Gene type: protein coding

About Gria1

Summary

Enables AMPA glutamate receptor activity; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in long-term memory; receptor internalization; and regulation of postsynaptic membrane potential. Acts upstream of or within cellular response to ammonium ion; chemical synaptic transmission; and long-term synaptic depression. Located in several cellular components, including dendrite membrane; neuron spine; and perisynaptic space. Is integral component of postsynaptic density membrane. Part of AMPA glutamate receptor complex. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study schizoaffective disorder. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Gria1 Products(3)

mRNA Protein Name
NM_001113325.2 NP_001106796.1 glutamate receptor 1 isoform 1 precursor
NM_001252403.1 NP_001239332.1 glutamate receptor 1 isoform 3
NM_008165.4 NP_032191.2 glutamate receptor 1 isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables AMPA glutamate receptor activity IDA
IDA: Inferred from direct assay
29490264 MGI
enables glutamate-gated receptor activity IDA
IDA: Inferred from direct assay
1699805 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12839988 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
11431570 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
11431570 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to ammonium ion IDA
IDA: Inferred from direct assay
24412196 MGI
acts upstream of or within chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
19657020 MGI
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
12628184 MGI
acts upstream of or within long-term synaptic depression IGI
IGI: Inferred from genetic interaction
24259587 MGI
involved in receptor internalization IMP
IMP: Inferred from mutant phenotype
12628184 MGI
involved in synapse assembly IMP
IMP: Inferred from mutant phenotype
22623657 MGI
Cellular Component GO Annotation Evidence Reference Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
1699805 MGI
located in axonal spine IDA
IDA: Inferred from direct assay
23303939 MGI
located in cell body IDA
IDA: Inferred from direct assay
23936366 MGI
is active in cell surface IDA
IDA: Inferred from direct assay
25918374 MGI
located in cell surface IDA
IDA: Inferred from direct assay
17229826 MGI
located in cell surface IMP
IMP: Inferred from mutant phenotype
17229826 MGI
located in dendrite IDA
IDA: Inferred from direct assay
21172611 MGI
located in dendrite membrane IDA
IDA: Inferred from direct assay
21795692 MGI
located in dendrite membrane IMP
IMP: Inferred from mutant phenotype
21795692 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
21172611 MGI
is active in dendritic spine membrane IDA
IDA: Inferred from direct assay
22623657 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16814779 MGI
is active in excitatory synapse IDA
IDA: Inferred from direct assay
25918374 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11431570 MGI
located in glutamatergic synapse IDA
IDA: Inferred from direct assay
25429150 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
11431570 MGI
part of ionotropic glutamate receptor complex IDA
IDA: Inferred from direct assay
15207857 MGI
located in membrane IDA
IDA: Inferred from direct assay
17093100 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
21558424 MGI
located in neuron spine IDA
IDA: Inferred from direct assay
16606358 MGI
is active in neuronal cell body IDA
IDA: Inferred from direct assay
25918374 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
16606358 MGI
located in perisynaptic space IDA
IDA: Inferred from direct assay
29490264 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
24412196 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16606358 MGI
located in postsynapse IDA
IDA: Inferred from direct assay
21144999 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
12628184 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
14555717 MGI
located in postsynaptic density membrane IDA
IDA: Inferred from direct assay
21172611 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
15207857 MGI
located in presynapse IDA
IDA: Inferred from direct assay
31651360 MGI
located in somatodendritic compartment IDA
IDA: Inferred from direct assay
18341993 MGI
located in synapse IDA
IDA: Inferred from direct assay
24259587 MGI
located in synaptic membrane IDA
IDA: Inferred from direct assay
23676497 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
20418887 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
29490264 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor 1

AMPA-selective glutamate receptor 1

glutamate receptor A

glutamate receptor ionotropic, AMPA 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05791 GRIA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gria1 NCBI NCBI:2890