Grik5 - glutamate receptor, ionotropic, kainate 5 (gamma 2) Gene

Mus musculus

Also known as KA2; GluK5; GluRgamma2

Gene ID: 14809 | Gene type: protein coding

About Grik5

Summary

Enables kainate selective glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within excitatory postsynaptic potential; glutamatergic synaptic transmission; and regulation of synaptic vesicle fusion to presynaptic active zone membrane. Located in endoplasmic reticulum; postsynaptic membrane; and presynaptic membrane. Part of kainate selective glutamate receptor complex. Is active in hippocampal mossy fiber to CA3 synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and visual system. Orthologous to human GRIK5 (glutamate ionotropic receptor kainate type subunit 5). [provided by Alliance of Genome Resources, Apr 2022]

Grik5 Products(5)

mRNA	Protein	Name
NM_001360067.2	NP_001346996.1	glutamate receptor ionotropic, kainate 5 isoform 2
NM_001402847.1	NP_001389776.1	glutamate receptor ionotropic, kainate 5 isoform 3 precursor
NM_001402848.1	NP_001389777.1	glutamate receptor ionotropic, kainate 5 isoform 4
NM_001402849.1	NP_001389778.1	glutamate receptor ionotropic, kainate 5 isoform 5
NM_008168.3	NP_032194.2	glutamate receptor ionotropic, kainate 5 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kainate selective glutamate receptor activity	IGI IGI: Inferred from genetic interaction	1310861	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16354929	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP EXP: Inferred from Experiment	22345355	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	22345355	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	22345355	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	12533602	MGI
acts upstream of or within regulation of membrane potential	IGI IGI: Inferred from genetic interaction	1310861	MGI
acts upstream of or within regulation of synaptic vesicle fusion to presynaptic active zone membrane	IMP IMP: Inferred from mutant phenotype	12533602	MGI
acts upstream of or within synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	12533602	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16814779	MGI
is active in hippocampal mossy fiber to CA3 synapse	EXP EXP: Inferred from Experiment	22345355	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	12954862	MGI
is active in hippocampal mossy fiber to CA3 synapse	IMP IMP: Inferred from mutant phenotype	22345355	MGI
part of kainate selective glutamate receptor complex	IPI IPI: Inferred from physical interaction	12954862	MGI
located in membrane	IDA IDA: Inferred from direct assay	12954862	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	12954862	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	12954862	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	12954862	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	12954862	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor ionotropic, kainate 5

gluR gamma-2	glutamate receptor KA-2
glutamate receptor gamma-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05802	GRIK5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grik5	NCBI	NCBI:2901

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