Grik5 - glutamate receptor, ionotropic, kainate 5 (gamma 2) Gene

Also Known as KA2; GluK5; GluRgamma2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14809

Summary

Enables kainate selective glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within excitatory postsynaptic potential; glutamatergic synaptic transmission; and regulation of synaptic vesicle fusion to presynaptic active zone membrane. Located in endoplasmic reticulum; postsynaptic membrane; and presynaptic membrane. Part of kainate selective glutamate receptor complex. Is active in hippocampal mossy fiber to CA3 synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and visual system. Orthologous to human GRIK5 (glutamate ionotropic receptor kainate type subunit 5). [provided by Alliance of Genome Resources, Apr 2022]

Grik5 Products (5)

mRNA Protein Name
NM_001360067.2 NP_001346996.1 glutamate receptor ionotropic, kainate 5 isoform 2
NM_001402847.1 NP_001389776.1 glutamate receptor ionotropic, kainate 5 isoform 3 precursor
NM_001402848.1 NP_001389777.1 glutamate receptor ionotropic, kainate 5 isoform 4
NM_001402849.1 NP_001389778.1 glutamate receptor ionotropic, kainate 5 isoform 5
NM_008168.3 NP_032194.2 glutamate receptor ionotropic, kainate 5 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kainate selective glutamate receptor activity IGI
IGI: Inferred from genetic interaction
1310861 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16354929 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential EXP
EXP: Inferred from Experiment
22345355 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
22345355 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
22345355 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
12533602 MGI
acts upstream of or within regulation of membrane potential IGI
IGI: Inferred from genetic interaction
1310861 MGI
acts upstream of or within regulation of synaptic vesicle fusion to presynaptic active zone membrane IMP
IMP: Inferred from mutant phenotype
12533602 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
12533602 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16814779 MGI
is active in hippocampal mossy fiber to CA3 synapse EXP
EXP: Inferred from Experiment
22345355 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
12954862 MGI
is active in hippocampal mossy fiber to CA3 synapse IMP
IMP: Inferred from mutant phenotype
22345355 MGI
part of kainate selective glutamate receptor complex IPI
IPI: Inferred from physical interaction
12954862 MGI
located in membrane IDA
IDA: Inferred from direct assay
12954862 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
12954862 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
12954862 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
12954862 MGI
located in presynaptic membrane IDA
IDA: Inferred from direct assay
12954862 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor ionotropic, kainate 5

  • gluR gamma-2

  • glutamate receptor KA-2

  • glutamate receptor gamma-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05802 GRIK5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grik5 NCBI NCBI:2901