GRIK5 - glutamate ionotropic receptor kainate type subunit 5 Gene

Also Known as KA2; EAA2; GRIK2; GluK5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2901

About GRIK5

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,998,324-42,070,206 (from NCBI)

This gene has 6 transcripts (splice variants), 301 orthologues and 17 paralogues. Broad expression in testis (RPKM 5.6), brain (RPKM 5.5) and 14 other tissues.

Summary

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GRIK5 Products (2)

mRNA Protein Name
NM_001301030.2 NP_001287959.1 glutamate receptor ionotropic, kainate 5 isoform 1 precursor
NM_002088.5 NP_002079.3 glutamate receptor ionotropic, kainate 5 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to glutamate-gated receptor activity IDA
IDA: Inferred from direct assay
8730589 GOA
enables kainate selective glutamate receptor activity IDA
IDA: Inferred from direct assay
1321949 GOA
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
18562611 GOA
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
18562611 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with plasma membrane IDA
IDA: Inferred from direct assay
14511640 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRIK5 Protein Structure

ANF_receptor

ANF_receptor: Receptor family ligand binding region (42 - 379)

Lig_chan-Glu_bd

Lig_chan-Glu_bd: Ligated ion channel L-glutamate- and glycine-binding site (426 - 490)

Lig_chan

Lig_chan: Ligand-gated ion channel (545 - 815)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 980 a.a.
Protein Preferred Names Protein Names

glutamate receptor ionotropic, kainate 5

  • excitatory amino acid receptor 2

Related Diseases

Diseases Alias
Brugada Syndrome 3

  • BRGDA3

  • Brugada Syndrome, Type 3
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Autosomal Recessive Intellectual Developmental Disorder

  • Mental Retardation, Autosomal Recessive

  • Autosomal Recessive Mental Retardation

  • Autosomal Recessive Non-Syndromic Mental Retardation

  • Autosomal Recessive Non-Syndromic Intellectual Disability
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05802 GRIK5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GRIK5 VGNC VGNC:41490
Macaca mulatta GRIK5 VGNC VGNC:73280
Felis catus GRIK5 VGNC VGNC:67470
Rattus norvegicus GRIK5 RGD RGD:2735
Bos taurus GRIK5 VGNC VGNC:57048
Mus musculus GRIK5 MGD MGI:95818
Others GRIK5 NCBI