GRIK5 - glutamate ionotropic receptor kainate type subunit 5 Gene

Homo sapiens

Also known as KA2; EAA2; GRIK2; GluK5

Gene ID: 2901 | Gene type: protein coding

About GRIK5

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,998,324-42,070,206 (from NCBI)

This gene has 6 transcripts (splice variants), 301 orthologues and 17 paralogues. Broad expression in testis (RPKM 5.6), brain (RPKM 5.5) and 14 other tissues.

Summary

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GRIK5 Products(2)

mRNA	Protein	Name
NM_001301030.2	NP_001287959.1	glutamate receptor ionotropic, kainate 5 isoform 1 precursor
NM_002088.5	NP_002079.3	glutamate receptor ionotropic, kainate 5 isoform 2 precursor

GRIK5 Protein Structure

ANF_receptor

Lig_chan-Glu_bd

Lig_chan

0
200
400
600
800
980 a.a.

Protein Preferred Names

Protein Names

glutamate receptor ionotropic, kainate 5

excitatory amino acid receptor 2

Related Diseases

Diseases

Alias

Brugada Syndrome 3

BRGDA3

Brugada Syndrome, Type 3

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05802	GRIK5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GRIK5	VGNC	VGNC:41490
Macaca mulatta	GRIK5	VGNC	VGNC:73280
Felis catus	GRIK5	VGNC	VGNC:67470
Rattus norvegicus	GRIK5	RGD	RGD:2735
Bos taurus	GRIK5	VGNC	VGNC:57048
Mus musculus	GRIK5	MGD	MGI:95818

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