Guca2b - guanylate cyclase activator 2b (retina) Gene

Also Known as Ugn; Gcap2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14916

Summary

This gene encodes a member of the guanylin family and preproprotein that is proteolytically processed to generate a mature protein product. The mature protein product, known as uroguanylin, is an endogenous ligand for the guanylate cyclase-C receptor and may regulate salt and water homeostasis in the intestine and kidneys. Homozygous knockout mice for this gene exhibit impaired sodium chloride excretion and elevated arterial pressure. This gene is present in a gene cluster with a related guanylin family member on chromosome 4. [provided by RefSeq, Sep 2015]

Guca2b Products (1)

mRNA Protein Name
NM_008191.2 NP_032217.2 guanylate cyclase activator 2B preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in adipose tissue development IMP
IMP: Inferred from mutant phenotype
24898144 MGI
acts upstream of or within body fluid secretion IMP
IMP: Inferred from mutant phenotype
14561709 MGI
involved in energy homeostasis IMP
IMP: Inferred from mutant phenotype
24898144 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
24898144 MGI
involved in multicellular organism growth IMP
IMP: Inferred from mutant phenotype
24898144 MGI
acts upstream of or within negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
14561709 MGI
involved in reduction of food intake in response to dietary excess IMP
IMP: Inferred from mutant phenotype
24898144 MGI
acts upstream of or within renal sodium ion absorption IMP
IMP: Inferred from mutant phenotype
14561709 MGI
involved in response to glucose IMP
IMP: Inferred from mutant phenotype
24898144 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanylate cyclase activator 2B

  • granule cell antiserum positive 2

  • uroguanylin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05917 GUCA2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Guca2b NCBI NCBI:2981