Guca2b - guanylate cyclase activator 2b (retina) Gene

Mus musculus

Also known as Ugn; Gcap2

Gene ID: 14916 | Gene type: protein coding

About Guca2b

Summary

This gene encodes a member of the guanylin family and preproprotein that is proteolytically processed to generate a mature protein product. The mature protein product, known as uroguanylin, is an endogenous ligand for the guanylate cyclase-C receptor and may regulate salt and water homeostasis in the intestine and kidneys. Homozygous knockout mice for this gene exhibit impaired sodium chloride excretion and elevated arterial pressure. This gene is present in a gene cluster with a related guanylin family member on chromosome 4. [provided by RefSeq, Sep 2015]

Guca2b Products(1)

mRNA	Protein	Name
NM_008191.2	NP_032217.2	guanylate cyclase activator 2B preproprotein

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in adipose tissue development	IMP IMP: Inferred from mutant phenotype	24898144	MGI
acts upstream of or within body fluid secretion	IMP IMP: Inferred from mutant phenotype	14561709	MGI
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	24898144	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	24898144	MGI
involved in multicellular organism growth	IMP IMP: Inferred from mutant phenotype	24898144	MGI
acts upstream of or within negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	14561709	MGI
involved in reduction of food intake in response to dietary excess	IMP IMP: Inferred from mutant phenotype	24898144	MGI
acts upstream of or within renal sodium ion absorption	IMP IMP: Inferred from mutant phenotype	14561709	MGI
involved in response to glucose	IMP IMP: Inferred from mutant phenotype	24898144	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

guanylate cyclase activator 2B

granule cell antiserum positive 2

uroguanylin

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05917	GUCA2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Guca2b	NCBI	NCBI:2981

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