GUCA2B - guanylate cyclase activator 2B Gene

Also Known as UGN; GCAP-II

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2981

About GUCA2B

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:42,153,410-42,155,820 (from NCBI)

This gene has 1 transcript (splice variant), 148 orthologues and 1 paralogue. Biased expression in small intestine (RPKM 47.4), colon (RPKM 37.0) and 1 other tissue.

Summary

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015]

GUCA2B Products (1)

mRNA Protein Name
NM_007102.3 NP_009033.1 guanylate cyclase activator 2B preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GUCA2B Protein Structure

Guanylin

Guanylin: Guanylin precursor (25 - 111)

  • 0
  • 100
  • 112 a.a.
Protein Preferred Names Protein Names

guanylate cyclase activator 2B

  • prepro-uroguanylin

GUCA2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GUCA2B Q16661 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
GUCA2B Q16661 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
GUCA2B Q16661 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
GUCA2B Q16661 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Cataract 8, Multiple Types

  • Ccv

  • Cataract, Congenital, Volkmann Type

  • CTRCT8

  • Cataract 8 Multiple Types

  • Cataract Congenital Volkmann Type

  • Cutaneous Collagenous Vasculopathy
Nephrotic Syndrome

  • Finnish Congenital Nephrotic Syndrome

  • Ns - [Nephrotic Syndrome]

  • Nephrosis Syndrome

  • Nephrosis Nos

  • Glomerular Lesion Nephrosis
Secretory Diarrhea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05917 GUCA2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GUCA2B MGD MGI:1270851
Bos taurus GUCA2B VGNC VGNC:29717
Rattus norvegicus GUCA2B RGD RGD:620044
Felis catus GUCA2B VGNC VGNC:67513
Canis familiaris GUCA2B VGNC VGNC:41565
Macaca mulatta GUCA2B VGNC VGNC:73326
Others GUCA2B NCBI