H2-Oa - histocompatibility 2, O region alpha locus Gene

Also Known as H-2Oa

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15001

Summary

Predicted to enable MHC class II protein complex binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and regulation of T cell differentiation. Predicted to be part of MHC class II protein complex. Is expressed in several structures, including central nervous system; cornea; genitourinary system; palatal shelf; and salivary gland. Human ortholog(s) of this gene implicated in occupational asthma. Orthologous to human HLA-DOA (major histocompatibility complex, class II, DO alpha). [provided by Alliance of Genome Resources, Apr 2022]

H2-Oa Products (1)

mRNA Protein Name
NM_008206.2 NP_032232.2 histocompatibility 2, O region alpha locus precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
11069069 MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
IMP: Inferred from mutant phenotype
9492004 MGI
acts upstream of or within regulation of T cell differentiation IMP
IMP: Inferred from mutant phenotype
11069069 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histocompatibility 2, O region alpha locus

  • MHC class II antigen O region alpha locus