2. Gene
  3. H3f3a - H3.3 histone A Gene

H3f3a - H3.3 histone A Gene

  • Gene
  • Protein
  • Agent
Mus musculus

Also known as H3-3a; H3-3b; H3.3A; EyeLinc14

Gene ID: 15078 | Gene type: protein coding

About H3f3a

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Nov 2015]

H3f3a Products(2)

mRNA Protein Name
NM_008210.6 NP_032236.1 histone H3.3
NM_008210.6 NP_032236.1 histone H3.3
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell population proliferation IGI
IGI: Inferred from genetic interaction
26159997 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
25675407 MGI
acts upstream of or within muscle cell differentiation IGI
IGI: Inferred from genetic interaction
22705305 MGI
acts upstream of or within negative regulation of chromosome condensation IGI
IGI: Inferred from genetic interaction
23903189 MGI
involved in oocyte maturation IDA
IDA: Inferred from direct assay
25645018 MGI
acts upstream of or within oogenesis IGI
IGI: Inferred from genetic interaction
25675407 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: Inferred from genetic interaction
22705305 MGI
acts upstream of or within pericentric heterochromatin formation IGI
IGI: Inferred from genetic interaction
26159997 MGI
acts upstream of or within single fertilization IMP
IMP: Inferred from mutant phenotype
25675407 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
25675407 MGI
acts upstream of or within subtelomeric heterochromatin formation IGI
IGI: Inferred from genetic interaction
26159997 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Barr body IDA
IDA: Inferred from direct assay
15657431 MGI
is active in chromatin IDA
IDA: Inferred from direct assay
25645018 MGI
is active in chromosome IDA
IDA: Inferred from direct assay
25645018 MGI
is active in chromosome, centromeric region IDA
IDA: Inferred from direct assay
25645018 MGI
part of inner kinetochore IDA
IDA: Inferred from direct assay
25645018 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone H3.3

H3 histone, family 3A

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05961 H3-3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown