Hes3 - hes family bHLH transcription factor 3 Gene

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including nervous system development; positive regulation of transcription by RNA polymerase II; and regulation of timing of neuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human HES3 (hes family bHLH transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]