2. Gene
  3. Hes3 - hes family bHLH transcription factor 3 Gene

Hes3 - hes family bHLH transcription factor 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Hes-3; bHLHb43

Gene ID: 15207 | Gene type: protein coding

About Hes3

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including nervous system development; positive regulation of transcription by RNA polymerase II; and regulation of timing of neuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human HES3 (hes family bHLH transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Hes3 Products(10)

mRNA Protein Name
NM_001403791.1 NP_001390720.1 transcription factor HES-3
NM_001403792.1 NP_001390721.1 transcription factor HES-3
NM_001403793.1 NP_001390722.1 transcription factor HES-3
NM_001403794.1 NP_001390723.1 transcription factor HES-3
NM_008237.5 NP_032263.2 transcription factor HES-3
NM_001403791.1 NP_001390720.1 transcription factor HES-3
NM_001403792.1 NP_001390721.1 transcription factor HES-3
NM_001403793.1 NP_001390722.1 transcription factor HES-3
NM_001403794.1 NP_001390723.1 transcription factor HES-3
NM_008237.5 NP_032263.2 transcription factor HES-3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10858455 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
10858455 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
10858455 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within hindbrain morphogenesis IGI
IGI: Inferred from genetic interaction
11500373 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
11500373 MGI
acts upstream of or within midbrain development IGI
IGI: Inferred from genetic interaction
11500373 MGI
acts upstream of or within midbrain-hindbrain boundary morphogenesis IGI
IGI: Inferred from genetic interaction
11522634 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10858455 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19050759 MGI
acts upstream of or within neural tube development IGI
IGI: Inferred from genetic interaction
11500373 MGI
acts upstream of or within oculomotor nerve development IGI
IGI: Inferred from genetic interaction
11500373 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
11500373 MGI
acts upstream of or within regulation of neurogenesis IGI
IGI: Inferred from genetic interaction
19050759 MGI
acts upstream of or within regulation of timing of neuron differentiation IGI
IGI: Inferred from genetic interaction
11500373 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19050759 MGI
acts upstream of or within trochlear nerve development IGI
IGI: Inferred from genetic interaction
11500373 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor HES-3

hairy and enhancer of split 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120782 Yhhu-3792 Activator 99.34% Unkown
HY-120782A Yhhu-3792 hydrochloride Activator / Unkown
HY-RS06136 HES3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hes3 NCBI NCBI:390992