Yhhu-3792 hydrochloride
Based on 2 publication(s) in Google Scholar
Yhhu-3792 hydrochloride is a Notch activator. Yhhu-3792 hydrochloride enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 hydrochloride promotes the expression of Hes3 and Hes5. Yhhu-3792 hydrochloride increases the spatial and episodic memory abilities of mice. Yhhu-3792 hydrochloride can be used for the study of neurodegenerative diseases (such as Alzheimer's disease) or for neural regeneration after brain injury .
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- CAS No.: 2624336-93-0
- Formule: C24H25ClN4O2
- Masse moléculaire:436.93
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Yhhu-3792 hydrochloride
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Activité biologique
Yhhu-3792 (0.63-2.5 μM, 8 d) hydrochloride increases the number of embryonic hippocampal neural stem cells (NSCs)[1].
Yhhu-3792 (0.63-2.5 μM, 2 d) hydrochloride activates the Notch signaling pathway and promotes the expression of Hes5 and Hes3 in neuro-spheres[1].
Yhhu-3792 (2.5 μM, 7-14 d) hydrochloride fails to significantly increase the proportion or purity of natural killer (NK) cell[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Rats neuro-spheres
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Concentration:0.63, 1.25, 2.5 μM
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Incubation Time:2 d
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Result:Increased the expression of Notch1 receptor, nuclear NICD, DLL1 and Jagged2.
Significantly increased the expression of Hes5 and Hes3 proteins.
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Cell Line:Rats neuro-spheres
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Concentration:0.63, 1.25, 2.5 μM
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Incubation Time:2 d
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Result:Increased the transcription levels of Hes5 and Hes3.
Significantly enhanced the binding of NICD to the promoters of Hes5 and Hes3.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Morris water maze (MWM) assay and fear conditioning (FC) assay established in eight-week-old male C57BL/6 mice[1]
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Dosage:10 and 20 mg/kg
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Administration:Intraperitoneal injection (i.p.), once daily for 3 weeks
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Result:Expanded the NSCs pool and promoted endogenous neurogenesis in the hippocampal dentate gyrus.
Decreased the escape latency of C57BL/6 mice in the MWM test.
increased the freezing time of mice in the Fear conditioning test.
Chemical Information
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CAS No. 2624336-93-0
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Masse moléculaire 436.93
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Formule C24H25ClN4O2
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SMILES
[H]Cl.NC1=C2C(OC3=CC=CC(OC)=C3)=CC=CC2=NC(NC4=CC=C(C(C)C)C=C4)=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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MedComm (2020)
Nitrate Enhances Gastric Mucosa Defense and Repair Process in Ethanol-Induced Gastric Ulcer Rats via the Notch-Tff2 Pathway. [Abstract]2026 Feb 5;7(2):e70628. PMID: 41660303 -
Int J Mol Sci
Bmp16 Regulates Arterial Valve Morphogenesis Through Modulation of Notch Signaling in Zebrafish. [Abstract]2026 Feb 24;27(5):2111. PMID: 41828338
Pureté et documentation
Références
[1]. Lu H, et al. A Novel 2-Phenylamino-Quinazoline-Based Compound Expands the Neural Stem Cell Pool and Promotes the Hippocampal Neurogenesis and the Cognitive Ability of Adult Mice. Stem Cells. 2018 Aug;36(8):1273-1285. [Content Brief]
[2]. Kunkanjanawan H, et al. Efficient large-scale expansion of cord blood-derived NK cells: leveraging lipopolysaccharide for enhanced NK cell production. Cytotherapy. 2025 Jun;27(6):782-789. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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