Yhhu-3792 hydrochloride

Cat. No.: HY-120782A: Ficha de datos Instrucciones de manejo
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Yhhu-3792 hydrochloride is a Notch activator. Yhhu-3792 hydrochloride enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 hydrochloride promotes the expression of Hes3 and Hes5. Yhhu-3792 hydrochloride increases the spatial and episodic memory abilities of mice. Yhhu-3792 hydrochloride can be used for the study of neurodegenerative diseases (such as Alzheimer's disease) or for neural regeneration after brain injury .

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Yhhu-3792 hydrochloride Estructura química

No. CAS : 2624336-93-0

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Other In-stock Forms of Yhhu-3792 hydrochloride:

Yhhu-3792

Other Forms of Yhhu-3792 hydrochloride:

Yhhu-3792 In-stock

2 Publications Citing Use of MCE Yhhu-3792 hydrochloride

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Actividad biológica
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Descripciòn

In Vitro

Yhhu-3792 (0.63-2.5 μM, 8 d) hydrochloride increases the number of embryonic hippocampal neural stem cells (NSCs)^[1].
Yhhu-3792 (0.63-2.5 μM, 2 d) hydrochloride activates the Notch signaling pathway and promotes the expression of Hes5 and Hes3 in neuro-spheres^[1].
Yhhu-3792 (2.5 μM, 7-14 d) hydrochloride fails to significantly increase the proportion or purity of natural killer (NK) cell^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	Rats neuro-spheres
Concentration:	0.63, 1.25, 2.5 μM
Incubation Time:	2 d
Result:	Increased the expression of Notch1 receptor, nuclear NICD, DLL1 and Jagged2. Significantly increased the expression of Hes5 and Hes3 proteins.

RT-PCR^[1]

Cell Line:	Rats neuro-spheres
Concentration:	0.63, 1.25, 2.5 μM
Incubation Time:	2 d
Result:	Increased the transcription levels of Hes5 and Hes3. Significantly enhanced the binding of NICD to the promoters of Hes5 and Hes3.

In Vivo

Yhhu-3792 (10-20 mg/kg, i.p., once daily for 3 weeks) hydrochloride enhances the self-renewal of the hippocampal NSCs and promotes the hippocampal neuro-genesis and improves the spatial learning and memory ability of mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Morris water maze (MWM) assay and fear conditioning (FC) assay established in eight-week-old male C57BL/6 mice^[1]
Dosage:	10 and 20 mg/kg
Administration:	Intraperitoneal injection (i.p.), once daily for 3 weeks
Result:	Expanded the NSCs pool and promoted endogenous neurogenesis in the hippocampal dentate gyrus. Decreased the escape latency of C57BL/6 mice in the MWM test. increased the freezing time of mice in the Fear conditioning test.

Peso molecular

436.93

Fòrmula

C₂₄H₂₅ClN₄O₂

No. CAS

2624336-93-0

SMILES

[H]Cl.NC1=C2C(OC3=CC=CC(OC)=C3)=CC=CC2=NC(NC4=CC=C(C(C)C)C=C4)=N1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Lu H, et al. A Novel 2-Phenylamino-Quinazoline-Based Compound Expands the Neural Stem Cell Pool and Promotes the Hippocampal Neurogenesis and the Cognitive Ability of Adult Mice. Stem Cells. 2018 Aug;36(8):1273-1285. [Content Brief]

[2]. Kunkanjanawan H, et al. Efficient large-scale expansion of cord blood-derived NK cells: leveraging lipopolysaccharide for enhanced NK cell production. Cytotherapy. 2025 Jun;27(6):782-789. [Content Brief]