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Foxj1 - forkhead box J1 Gene

Also Known as Hfh4; HFH-4; FKHL-13

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15223

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; negative regulation of lymphocyte activation; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; establishment of apical/basal cell polarity; and left/right pattern formation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; nose; and respiratory system. Used to study Kartagener syndrome and primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 43. Orthologous to human FOXJ1 (forkhead box J1). [provided by Alliance of Genome Resources, Apr 2022]

Foxj1 Products (1)

mRNA	Protein	Name
NM_008240.3	NP_032266.3	forkhead box protein J1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9096351	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9096351	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	17488776	MGI
involved in activation of GTPase activity	IDA IDA: Inferred from direct assay	17488776	MGI
involved in brain development	IEP IEP: Inferred from expression pattern	9096351	MGI
acts upstream of or within cell maturation	IDA IDA: Inferred from direct assay	29452604	MGI
acts upstream of or within cell maturation	IMP IMP: Inferred from mutant phenotype	29452604	MGI
involved in central tolerance induction	IMP IMP: Inferred from mutant phenotype	16339515	MGI
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	9739041	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in epithelium development	IEP IEP: Inferred from expression pattern	9096351	MGI
acts upstream of or within establishment of apical/basal cell polarity	IMP IMP: Inferred from mutant phenotype	14996907	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in humoral immune response	IMP IMP: Inferred from mutant phenotype	16339515	MGI
acts upstream of or within left/right pattern formation	IMP IMP: Inferred from mutant phenotype	10873152	MGI
involved in leukocyte migration	IMP IMP: Inferred from mutant phenotype	16339515	MGI
acts upstream of or within motile cilium assembly	IGI IGI: Inferred from genetic interaction	22357932	MGI
involved in motile cilium assembly	IMP IMP: Inferred from mutant phenotype	10873152	MGI
involved in negative regulation of B cell activation	IMP IMP: Inferred from mutant phenotype	16002694	MGI
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	16002694	MGI
involved in negative regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	16339515	MGI
involved in negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	14963332	MGI
involved in negative regulation of germinal center formation	IMP IMP: Inferred from mutant phenotype	16002694	MGI
involved in negative regulation of humoral immune response mediated by circulating immunoglobulin	IMP IMP: Inferred from mutant phenotype	16002694	MGI
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16002694	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16002694	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27914912	MGI
involved in positive regulation of central B cell tolerance induction	IMP IMP: Inferred from mutant phenotype	16002694	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16574095	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9096351	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	31884020	MGI
acts upstream of or within regulation of epithelial cell differentiation	IDA IDA: Inferred from direct assay	16574095	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	9096351	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
forkhead box protein J1	HNF-3/forkhead homolog 4 forkhead-related protein FKHL13 hepatocyte nuclear factor 3 forkhead homolog 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163982	FOXJ1 agonist 1	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxj1	NCBI	NCBI:2302