Foxf1 - forkhead box F1 Gene

Also Known as Hfh8; HFH-8; FREAC1; Foxf1a; Freac-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15227

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; respiratory system; and urethra. Used to study persistent fetal circulation syndrome. Human ortholog(s) of this gene implicated in persistent fetal circulation syndrome. Orthologous to human FOXF1 (forkhead box F1). [provided by Alliance of Genome Resources, Apr 2022]

Foxf1 Products (1)

mRNA Protein Name
NM_010426.3 NP_034556.2 forkhead box protein F1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15987774 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
7958446 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
11809759 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
11124112 MGI
acts upstream of or within cellular response to cytokine stimulus IDA
IDA: Inferred from direct assay
9486531 MGI
acts upstream of or within cellular response to organic cyclic compound IMP
IMP: Inferred from mutant phenotype
18421012 MGI
acts upstream of or within detection of wounding IMP
IMP: Inferred from mutant phenotype
12500195 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
11493558 MGI
acts upstream of or within embryonic digestive tract development IGI
IGI: Inferred from genetic interaction
16439479 MGI
acts upstream of or within embryonic foregut morphogenesis IMP
IMP: Inferred from mutant phenotype
11493558 MGI
acts upstream of or within epithelial cell differentiation involved in mammary gland alveolus development IGI
IGI: Inferred from genetic interaction
16691571 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
11493558 MGI
acts upstream of or within establishment of epithelial cell apical/basal polarity IGI
IGI: Inferred from genetic interaction
16439479 MGI
acts upstream of or within extracellular matrix organization IGI
IGI: Inferred from genetic interaction
16439479 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
11124112 MGI
acts upstream of or within lateral mesodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
11124112 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
11493558 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
11437453 MGI
acts upstream of or within lung lobe morphogenesis IMP
IMP: Inferred from mutant phenotype
11493558 MGI
acts upstream of or within lung morphogenesis IMP
IMP: Inferred from mutant phenotype
11493558 MGI
acts upstream of or within mesenchyme migration IMP
IMP: Inferred from mutant phenotype
17261592 MGI
acts upstream of or within mesoderm development IGI
IGI: Inferred from genetic interaction
11124112 MGI
acts upstream of or within mesoderm development IMP
IMP: Inferred from mutant phenotype
11493558 MGI
acts upstream of or within mesodermal cell differentiation IGI
IGI: Inferred from genetic interaction
17881493 MGI
acts upstream of or within mesodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
17881493 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
18421012 MGI
acts upstream of or within negative regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
18421012 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11124112 MGI
acts upstream of or within positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
17261592 MGI
acts upstream of or within positive regulation of cell-substrate adhesion IMP
IMP: Inferred from mutant phenotype
17261592 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
11124112 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7958446 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17261592 MGI
acts upstream of or within right lung morphogenesis IMP
IMP: Inferred from mutant phenotype
11493558 MGI
acts upstream of or within smooth muscle cell differentiation IGI
IGI: Inferred from genetic interaction
17881493 MGI
acts upstream of or within smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
11493558 MGI
acts upstream of or within smoothened signaling pathway IDA
IDA: Inferred from direct assay
11493558 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
11124112 MGI
acts upstream of or within trachea development IMP
IMP: Inferred from mutant phenotype
11493558 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
11124112 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
17261592 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein F1

  • HNF-3/forkhead homolog 8

  • forkhead box F1a

  • forkhead-related protein FKHL5

  • forkhead-related transcription factor 1

  • hepatocyte nuclear factor 3 forkhead homolog 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05049 FOXF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18387 Foxf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24868 Foxf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxf1 NCBI NCBI:2294