FOXF1 - forkhead box F1 Gene

Also Known as FKHL5; ACDMPV; FREAC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2294

About FOXF1

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:86,510,527-86,515,422 (from NCBI)

This gene has 1 transcript (splice variant), 187 orthologues, 42 paralogues and is associated with 3 phenotypes. Biased expression in lung (RPKM 22.1), urinary bladder (RPKM 21.5) and 12 other tissues.

Summary

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]

FOXF1 Products (1)

mRNA	Protein	Name
NM_001451.3	NP_001442.2	forkhead box protein F1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9769171	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	8626802	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	8626802	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in blood vessel development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in cardiac left ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in digestive tract development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in ductus arteriosus closure	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in embryonic ectodermal digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in endocardial cushion development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in heart development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in in utero embryonic development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in lung development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in lung vasculature development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in midgut development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in morphogenesis of a branching structure	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in pancreas development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8626802	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	8626802	GOA
involved in respiratory tube development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in trachea development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in ureter development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in venous blood vessel development	IMP IMP: Inferred from mutant phenotype	19500772	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXF1 Protein Structure

Forkhead

0
100
200
300
379 a.a.

Protein Preferred Names	Protein Names
forkhead box protein F1	FREAC-1

FOXF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82936	FOXF1 Antibody (YA2681)	WB, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins	Alveolar Capillary Dysplasia ACDMPV Alveolar Capillary Dysplasia With Pulmonary Venous Misalignment Congenital Alveolar Capillary Dysplasia Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins And Other Congenital Anomalies Familial Persistent Pulmonary Hypertension Of The Newborn Acd Pulmonary Hypertension, Familial Persistent Of The Newborn Acd/Mpv Misalignment Of The Pulmonary Vessels Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Vessels Dysplasia, Capillary, Alveolar, With Misalignment Of Pulmonary Veins Persistent Fetal Circulation Syndrome
Idiopathic/Heritable Pulmonary Arterial Hypertension	Idiopathic And/Or Familial Pulmonary Arterial Hypertension
Atresia Of Urethra	Urethral Atresia
Vacterl Association	Vater Association Vater Syndrome
Pyloric Stenosis, Infantile Hypertrophic, 5	IHPS5
Ventricular Septal Defect	Ventricular Septal Defects Interventricular Septal Defect Heart Septal Defects, Ventricular Ventricular Septal Abnormality Interventricular Septum Defect Ventricular Septum Defect Vsd - [Ventricular Septum Defect] Congenital Ventricular Septal Defect Single Ventricular Septal Defect
Pancreas, Annular	Annular Pancreas Pancreas Annulare Congenital Annular Pancreas
Pyloric Stenosis
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Anus, Imperforate	Imperforate Anus Anorectal Malformation Anal Atresia Anorectal Malformations Congenital Atresia Of Anus Congenital Or Infantile Occlusion Of Anus Anal Stenosis Arm
Neonatal Respiratory Failure	Respiratory Failure Of Newborn Inadequate Pulmonary Ventilation Of Newborn Newborn Lung Insufficiency Newborn Pulmonary Function Inadequate Newborn Pulmonary Insufficiency Newborn Respiration Failure Newborn Respiratory Insufficiency Respiratory Insufficiency Syndrome Of Newborn
Duodenal Atresia	Duodenal Stenosis Familial Duodenal Atresia
Volvulus Of Midgut	Volvulus Intestinal Volvulus Intestinal Malrotation, Familial Familial Intestinal Malrotation Twist Of Intestine, Bowel, Or Colon
Pallister-Hall Syndrome	PHS Hypothalamic Hamartomas Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly Hypothalamic Hamartoblastoma Syndrome Hamartoma Of The Hypothalamus Pallister Hall Syndrome Hall-Pallister Syndrome Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly Hamartoma, Hypothalamic
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Microphthalmia, Syndromic 3	MCOPS3 Aeg Syndrome Microphthalmia And Esophageal Atresia Syndrome Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome Anophthalmia-Esophageal-Genital Syndrome Optic Nerve Hypoplasia And Abnormalities Of The Central Nervous System Syndromic Microphthalmia 3 Sox2 Anophthalmia Syndrome Anophthalmia Clinical With Associated Anomalies Anophthalmia Esophageal Genital Syndrome Anophthalmia Microphthalmia Esophageal Atresia Syndromic Microphthalmia Type 3 Sox2-Related Eye Disorders Anophthalmia, Clinical, With Associated Anomalies Syndromic Microphthalmia, Type 3 Microphthalmia, Syndromic, 3 Anophthalmia/Microphthalmia-Esophageal Atresia Microphthalmia Syndromic, Type 3
Intestinal Atresia
Omphalocele	Omphalocoele Congenital Omphalocele Exomphalos Exumbilication
Tracheomalacia	Congenital Tracheomalacia Congenital Major Airway Collapse Tracheomalacia, Congenital Type 1 Tracheomalacia
Hernia, Hiatus	Hiatal Hernia Hiatus Hernia Diaphragmatic - Hiatus -Hernia Hernia, Hiatal
Tracheal Stenosis	Stenosis Of Trachea
Vacterl Association, X-Linked, With Or Without Hydrocephalus	VACTERLX X-Linked Vacterl Association Vacterl-H, X-Linked Vacterl Association, X-Linked Vacterl Association, X-Linked With Or Without Hydrocephalus Vacterl Association X-Linked With Or Without Hydrocephalus Vacterl Syndrome Vertebral Anal Tracheoesophageal Esophageal Radial Anomalies X-Linked Vacterl-H Vacterl Association Vacterl Association With Hydrocephalus
Anus Disease	Anal Fissure Ulcer Of Anus Anus Diseases Anal Disease Anal Fissure And Fistula Anal Ulcer Fissure In Ano Nontraumatic Tear Of Anus Solitary Anal Ulcer Abnormality Of The Anus Anal Disorders Ulcer Of Anus And Rectum Solitary Ulcer Of Anus Stercoral Ulcer Of Anus
Tracheal Disease	Tracheal Diseases Tracheal Anomaly Tracheal Disorders
Astigmatism
Feingold Syndrome 1	Feingold Syndrome Oculodigitoesophagoduodenal Syndrome Oded Syndrome Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum FGLDS1 Mmt Syndrome Brunner-Winter Syndrome Feingold Syndrome Type 1 Oded Moded Fglds Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Moded Syndrome Oculo-Digito-Esophageal-Duodenal Syndrome Microcephaly, Mental Retardation, And Tracheoesophageal Fistula Syndrome Microcephaly And Digital Abnormalities With Normal Intelligence Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus, Or Duodenum Microcephaly-Mesobrachyphalangy-Tracheoesophageal Fistula Syndrome Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Oculo-Digito-Esophagoduodental Syndrome Fs Mmt Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome Brunner-Winter Syndrome Type 1 Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum Type 1 Fs1 Mmt Type 1 Moded Syndrome Type 1 Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Type 1 Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Type 1 Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome Type 1 Oded Syndrome Type 1 Oculo-Digito-Esophageal-Duodenal Syndrome Type 1 Feingold Syndrome, Type 1
Rhabdomyosarcoma
Hypoplastic Left Heart Syndrome	Hlhs Heart, Hypoplastic Left, Syndrome Hypoplasia Of The Left Heart Left Heart Hypoplasia Syndrome Hlhs - [Hypoplastic Left Heart Syndrome] Hypoplasia Of Aortic Valve, In Hypoplastic Left Heart Syndrome Atresia Of Mitral Valve, In Hypoplastic Left Heart Syndrome Atresia Or Marked Hypoplasia Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle Atresia Or Marked Hypoplasia, Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle With Mitral Valve Atresia Aortic Valve Atresia, In Hypoplastic Left Heart Syndrome Ascending Aorta Hypoplasia, In Hypoplastic Left Heart Syndrome
Rectal Disease	Rectal Diseases Rectal Disorders
Diaphragmatic Hernia, Congenital	Congenital Diaphragmatic Hernia Diaphragmatic Hernia Cdh Congenital Diaphragmatic Defect Hernia, Diaphragmatic Dih Hernia, Congenital Diaphragmatic Hcd Diaphragmatic Defect, Congenital Diaphragm, Unilateral Agenesis Of Hemidiaphragm, Agenesis Of Diaphragmatic Hernia 1 Agenesis Of Hemidiaphragm Unilateral Agenesis Of Diaphragm Hernia Diaphragmatic Hernia Diaphragmatic Congenital Hernia, Diaphragmatic, Type 1 Hiatus Hernia Oesophageal Hiatus Hernia Paraoesophageal Hernia Sliding Hiatus Hernia Congenital Diaphragm Hernia Congenital Diaphragm Defect With Hernia Gross Congenital Diaphragm Defect
Patent Ductus Arteriosus 1	Patent Ductus Arteriosus PDA1 Pda Ductus Arteriosus, Patent Patent Ductus Arteriosus, Susceptibility To Patent Ductus Botalli Patency Of The Ductus Arteriosus Patent Ductus Arteriosus Familial Ductus Arteriosus Patent Patent Ductus Arteriosus - Persisting Type
Atrial Heart Septal Defect	Atrial Septal Defect Atrial Septal Defects Atrioseptal Defect Auricular Septal Defect Congenital Atrial Septal Defect Interatrial Septal Defect Interauricular Septal Defect Heart Septal Defects, Atrial Septal Defect, Atrial
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05049	FOXF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18387	Foxf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24868	Foxf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FOXF1	RGD	RGD:1584229
Macaca mulatta	FOXF1	VGNC	VGNC:104726
Canis familiaris	FOXF1	VGNC	VGNC:40949
Bos taurus	FOXF1	VGNC	VGNC:29084
Felis catus	FOXF1	VGNC	VGNC:62332
Mus musculus	FOXF1	MGD	MGI:1347470
Others	FOXF1	NCBI