Hhex - hematopoietically expressed homeobox Gene

Also Known as Hex; Prh; Hex1; Prhx; Hhex-rs2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15242

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of transcription, DNA-templated; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; hepatic duct development; and primitive streak formation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; gut; liver and biliary system; and metanephros. Orthologous to human HHEX (hematopoietically expressed homeobox). [provided by Alliance of Genome Resources, Apr 2022]

Hhex Products (1)

mRNA Protein Name
NM_008245.3 NP_032271.1 hematopoietically-expressed homeobox protein Hhex

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11139473 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16764824 MGI
enables HMG box domain binding IPI
IPI: Inferred from physical interaction
16582099 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16764824 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16764824 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20028982 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell differentiation IMP
IMP: Inferred from mutant phenotype
12522149 MGI
involved in B cell differentiation IMP
IMP: Inferred from mutant phenotype
12522149 MGI
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
25446530 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
14736744 MGI
involved in anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
16936074 MGI
acts upstream of or within common bile duct development IMP
IMP: Inferred from mutant phenotype
17580084 MGI
acts upstream of or within embryonic heart tube development IMP
IMP: Inferred from mutant phenotype
15459110 MGI
acts upstream of or within embryonic organ development IMP
IMP: Inferred from mutant phenotype
16364283 MGI
acts upstream of or within endoderm development IMP
IMP: Inferred from mutant phenotype
16364283 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
10804184 MGI
acts upstream of or within forebrain morphogenesis IMP
IMP: Inferred from mutant phenotype
21445260 MGI
acts upstream of or within gallbladder development IMP
IMP: Inferred from mutant phenotype
17580084 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
12791650 MGI
acts upstream of or within hepatic duct development IMP
IMP: Inferred from mutant phenotype
17580084 MGI
acts upstream of or within hepatoblast differentiation IMP
IMP: Inferred from mutant phenotype
17580084 MGI
acts upstream of or within hepatocyte differentiation IMP
IMP: Inferred from mutant phenotype
11027604 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
21445260 MGI
acts upstream of or within interkinetic nuclear migration IMP
IMP: Inferred from mutant phenotype
16364283 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
10804184 MGI
acts upstream of or within morphogenesis of an epithelium IMP
IMP: Inferred from mutant phenotype
17580084 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
21445260 MGI
acts upstream of or within myeloid leukocyte differentiation IMP
IMP: Inferred from mutant phenotype
11027604 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10804173 MGI
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
12588764 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10804173 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10804173 MGI
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
12588764 MGI
acts upstream of or within pancreas development IMP
IMP: Inferred from mutant phenotype
16364283 MGI
involved in positive regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
16936074 MGI
acts upstream of or within primary lung bud formation IMP
IMP: Inferred from mutant phenotype
16364283 MGI
acts upstream of or within primitive streak formation IGI
IGI: Inferred from genetic interaction
21445260 MGI
acts upstream of or within primitive streak formation IMP
IMP: Inferred from mutant phenotype
21445260 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
14736744 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21445260 MGI
acts upstream of or within signal transduction IMP
IMP: Inferred from mutant phenotype
21445260 MGI
acts upstream of or within thyroid gland development IMP
IMP: Inferred from mutant phenotype
10804184 MGI
acts upstream of or within tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
21445260 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
12791650 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16854221 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11044484 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hematopoietically-expressed homeobox protein Hhex

  • hematopoietically expressed homeobox, related sequence 2

  • homeobox protein HEX

  • homeobox protein PRH

  • mHex

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06159 HHEX Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hhex NCBI NCBI:3087