Hhex - hematopoietically expressed homeobox Gene

Mus musculus

Also known as Hex; Prh; Hex1; Prhx; Hhex-rs2

Gene ID: 15242 | Gene type: protein coding

About Hhex

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of transcription, DNA-templated; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; hepatic duct development; and primitive streak formation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; gut; liver and biliary system; and metanephros. Orthologous to human HHEX (hematopoietically expressed homeobox). [provided by Alliance of Genome Resources, Apr 2022]

Hhex Products(1)

mRNA	Protein	Name
NM_008245.3	NP_032271.1	hematopoietically-expressed homeobox protein Hhex

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11139473	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16764824	MGI
enables HMG box domain binding	IPI IPI: Inferred from physical interaction	16582099	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16764824	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16764824	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20028982	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell differentiation	IMP IMP: Inferred from mutant phenotype	12522149	MGI
involved in B cell differentiation	IMP IMP: Inferred from mutant phenotype	12522149	MGI
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	25446530	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	14736744	MGI
involved in anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	16936074	MGI
acts upstream of or within common bile duct development	IMP IMP: Inferred from mutant phenotype	17580084	MGI
acts upstream of or within embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	15459110	MGI
acts upstream of or within embryonic organ development	IMP IMP: Inferred from mutant phenotype	16364283	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	16364283	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	10804184	MGI
acts upstream of or within forebrain morphogenesis	IMP IMP: Inferred from mutant phenotype	21445260	MGI
acts upstream of or within gallbladder development	IMP IMP: Inferred from mutant phenotype	17580084	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	12791650	MGI
acts upstream of or within hepatic duct development	IMP IMP: Inferred from mutant phenotype	17580084	MGI
acts upstream of or within hepatoblast differentiation	IMP IMP: Inferred from mutant phenotype	17580084	MGI
acts upstream of or within hepatocyte differentiation	IMP IMP: Inferred from mutant phenotype	11027604	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	21445260	MGI
acts upstream of or within interkinetic nuclear migration	IMP IMP: Inferred from mutant phenotype	16364283	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	10804184	MGI
acts upstream of or within morphogenesis of an epithelium	IMP IMP: Inferred from mutant phenotype	17580084	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	21445260	MGI
acts upstream of or within myeloid leukocyte differentiation	IMP IMP: Inferred from mutant phenotype	11027604	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10804173	MGI
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	12588764	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10804173	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10804173	MGI
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	12588764	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	16364283	MGI
involved in positive regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16936074	MGI
acts upstream of or within primary lung bud formation	IMP IMP: Inferred from mutant phenotype	16364283	MGI
acts upstream of or within primitive streak formation	IGI IGI: Inferred from genetic interaction	21445260	MGI
acts upstream of or within primitive streak formation	IMP IMP: Inferred from mutant phenotype	21445260	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	14736744	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21445260	MGI
acts upstream of or within signal transduction	IMP IMP: Inferred from mutant phenotype	21445260	MGI
acts upstream of or within thyroid gland development	IMP IMP: Inferred from mutant phenotype	10804184	MGI
acts upstream of or within tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	21445260	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	12791650	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16854221	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11044484	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hematopoietically-expressed homeobox protein Hhex

hematopoietically expressed homeobox, related sequence 2	homeobox protein HEX
homeobox protein PRH	mHex

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06159	HHEX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hhex	NCBI	NCBI:3087

Name
Email *

	Sorry, but the email address you supplied was invalid.