HHEX - hematopoietically expressed homeobox Gene

Also Known as HEX; PRH; HMPH; PRHX; HOX11L-PEN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3087

About HHEX

Cytogenetic location: 10q23.33 Genomic coordinates (GRCh38): 10:92,689,955-92,695,647 (from NCBI)

This gene has 4 transcripts (splice variants) and 116 orthologues. Broad expression in thyroid (RPKM 53.2), liver (RPKM 28.6) and 14 other tissues.

Summary

This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]

HHEX Products (1)

mRNA	Protein	Name
NM_002729.5	NP_002720.1	hematopoietically-expressed homeobox protein HHEX

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding, bending	IDA IDA: Inferred from direct assay	18755198	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	20028982	GOA
enables DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	15187083	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15016828	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15016828	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15016828	GOA
enables eukaryotic initiation factor 4E binding	IDA IDA: Inferred from direct assay	12554669	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10597310	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	16540119	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10871399	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18755198	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA conformation change	IDA IDA: Inferred from direct assay	18755198	GOA
involved in mRNA export from nucleus	IDA IDA: Inferred from direct assay	12554669	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10871399	GOA
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12554669	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10871399	GOA
involved in poly(A)+ mRNA export from nucleus	IMP IMP: Inferred from mutant phenotype	12554669	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20028982	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20028982	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12655000	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20028982	GOA
involved in protein localization to nucleus	IDA IDA: Inferred from direct assay	18713067	GOA
involved in regulation of leukocyte proliferation	IDA IDA: Inferred from direct assay	12554669	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12554669	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12554669	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	18755198	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HHEX Protein Structure

Homeobox

0
100
200
270 a.a.

Protein Preferred Names	Protein Names
hematopoietically-expressed homeobox protein HHEX	homeobox protein HEX

HHEX Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HHEX	Q03014	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	HHEX	Q03014	KRTAP10-5	Homo sapiens	P60370	Validated Y2H	25416956
Intra	HHEX	Q03014	KRTAP10-5	Homo sapiens	P60370	Y2H Prey Pooling	25416956
Intra	HHEX	Q03014	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	HHEX	Q03014	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	HHEX	Q03014	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	HHEX	Q03014	APOBEC3C	Homo sapiens	Q9NRW3	Y2H Array	32296183
Intra	HHEX	Q03014	APOBEC3C	Homo sapiens	Q9NRW3	Validated Y2H	32296183
Intra	HHEX	Q03014	APOBEC3C	Homo sapiens	Q9NRW3	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	PSTPIP1	Homo sapiens	O43586	Y2H Array	32296183
Intra	HHEX	Q03014	PSTPIP1	Homo sapiens	O43586	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	HHEX	Q03014	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	HHEX	Q03014	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	HHEX	Q03014	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	HHEX	Q03014	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	ABI1	Homo sapiens	Q8IZP0-5	Y2H Array	32296183
Intra	HHEX	Q03014	ABI1	Homo sapiens	Q8IZP0-5	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	ABI1	Homo sapiens	Q8IZP0-5	Validated Y2H	32296183
Intra	HHEX	Q03014	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	HHEX	Q03014	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	HHEX	Q03014	TP53BP2	Homo sapiens	Q05BL1	Validated Y2H	32296183
Intra	HHEX	Q03014	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	HHEX	Q03014	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	HHEX	Q03014	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	KRTAP5-7	Homo sapiens	Q6L8G8	Validated Y2H	32296183
Intra	HHEX	Q03014	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	HHEX	Q03014	KRTAP10-6	Homo sapiens	P60371	Y2H Array	32296183
Intra	HHEX	Q03014	KRTAP10-6	Homo sapiens	P60371	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	KRTAP6-1	Homo sapiens	Q3LI64	Validated Y2H	32296183
Intra	HHEX	Q03014	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	HHEX	Q03014	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	KRTAP5-8	Homo sapiens	O75690	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	KRTAP5-8	Homo sapiens	O75690	Y2H Array	32296183
Intra	HHEX	Q03014	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	KRTAP19-1	Homo sapiens	Q8IUB9	Validated Y2H	32296183
Intra	HHEX	Q03014	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Array	32296183
Intra	HHEX	Q03014	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Array	32296183
Intra	HHEX	Q03014	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	KRTAP2-4	Homo sapiens	Q9BYR9	Validated Y2H	32296183
Intra	HHEX	Q03014	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	HHEX	Q03014	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	HHEX	Q03014	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	PFDN5	Homo sapiens	Q99471	Validated Y2H	32296183
Intra	HHEX	Q03014	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	HHEX	Q03014	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	HHEX	Q03014	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	HHEX	Q03014	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	HHEX	Q03014	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	HHEX	Q03014	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	HHEX	Q03014	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	HHEX	Q03014	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	KHDRBS2	Homo sapiens	Q5VWX1	Validated Y2H	32296183
Intra	HHEX	Q03014	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	32296183
Intra	HHEX	Q03014	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	32296183
Intra	HHEX	Q03014	RBMY1F	Homo sapiens	Q15415	Validated Y2H	32296183
Intra	HHEX	Q03014	RBMY1F	Homo sapiens	Q15415	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

HHEX Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82157	Hex Antibody (YA1902)	WB, IP	Human

Related Diseases

Diseases	Alias
Intermittent Proptosis	Intermittent Exophthalmos
Cyclotropia
Heart Defects, Congenital, And Other Congenital Anomalies	Pancreatic Hypoplasia-Diabetes-Congenital Heart Disease Syndrome Pancreatic Agenesis And Congenital Heart Defects HDCA PACHD Congenital Pancreatic Hypoplasia With Diabetes Mellitus And Congenital Heart Disease Yorifuji-Okuno Syndrome Yorifuji Okuno Syndrome Pancreatic Hypoplasia, Congenital, With Diabetes Mellitus And Congenital Heart Disease Congenital Heart Defects And Other Congenital Anomalies Hereditary Pancreatic Hypoplasia, Diabetes Mellitus And Congenital Heart Disease Congenital Pancreatic Agenesis With Diabetes Mellitus And Congenital Heart Disease Heart Disease, Congenital, And Other Congenital Anomalies
Wolfram Syndrome 1	WFS1 Didmoad Wfs Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome Wolfram Syndrome
Thyroid Malformation
Psammomatous Meningioma
Sandhoff Disease	Total Hexosaminidase Deficiency Hexosaminidases A And B Deficiency Sandhoff Disease, Infantile, Juvenile, And Adult Forms Beta-Hexosaminidase-Beta-Subunit Deficiency Gm2 Gangliosidosis, Type 2 Hexosaminidase A And B Deficiency Disease Sandhoff-Jatzkewitz-Pilz Disease Gm2 Gangliosidosis, Type Ii Sandhoff Disease, Infantile Form Sandhoff Disease, Adult Form Sandhoff Disease, Juvenile Form Gm2-Gangliosidosis, Type Ii Sandhoff Jatzkewitz Disease Type Ii Gm2 Gangliosidosis Gm2 Gangliosidosis, 0 Variant Gm2 Gangliosidosis 0 Variant Hexosaminidases A And B Deficiency, Infantile Form Infantile Gm2 Gangliosidosis 0 Variant Adult Gm2 Gangliosidosis 0 Variant Hexosaminidases A And B Deficiency, Adult Form Hexosaminidases A And B Deficiency, Juvenile Form Juvenile Gm2 Gangliosidosis 0 Variant Gm2-Gangliosidosis 2 GM2G2 Hexosaminidase A And B Deficiency Sd
Gm2 Gangliosidosis	Gangliosidosis Gm2 Gangliosidoses, Gm2
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Diabetes Mellitus	Diabetes
Tay-Sachs Disease	Hexosaminidase A Deficiency TSD Hexa Deficiency Gm2 Gangliosidosis, Type 1 Hexosaminidase Alpha-Subunit Deficiency Gm2-Gangliosidosis, Several Forms Gm2-Gangliosidosis, B, B1, Ab Variant B Variant Gm2 Gangliosidosis Sphingolipidosis, Tay-Sachs Gm2-Gangliosidosis, Type I B Variant Gm2-Gangliosidosis Hex A Pseudodeficiency Hexa Disorders Beta-Hexosaminidase A Deficiency Gm2 Gangliosidosis, Type I Gangliosidosis Gm2 , Type 1 Gm2 Gangliosidosis, B, B1 Variant Gm2-Gangliosidosis 1 GM2G1 Gm2-Gangliosidosis B Variant Tay-Sachs Disease Pseudo-Ab Variant Tay-Sachs Disease Variant B1 Gangliosidoses, Gm2
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06159	HHEX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HHEX	VGNC	VGNC:41680
Rattus norvegicus	HHEX	RGD	RGD:619932
Mus musculus	HHEX	MGD	MGI:96086
Felis catus	HHEX	VGNC	VGNC:67568
Macaca mulatta	HHEX	VGNC	VGNC:73376
Bos taurus	HHEX	VGNC	VGNC:29839
Others	HHEX	NCBI