APOBEC3C - apolipoprotein B mRNA editing enzyme catalytic subunit 3C Gene

Also Known as A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27350

About APOBEC3C

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,014,257-39,020,352 (from NCBI)

This gene has 2 transcripts (splice variants), 55 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 33.1), testis (RPKM 26.8) and 24 other tissues.

Summary

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing Enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]

APOBEC3C Products (1)

mRNA Protein Name
NM_014508.3 NP_055323.2 DNA dC->dU-editing enzyme APOBEC-3C

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22915799 GOA
Biological Process GO Annotation Evidence References Source
involved in clearance of foreign intracellular DNA IDA
IDA: Inferred from direct assay
20062055 GOA
involved in cytidine deamination IDA
IDA: Inferred from direct assay
21632763 GOA
involved in negative regulation of viral genome replication IDA
IDA: Inferred from direct assay
21632763 GOA
involved in positive regulation of gene expression via chromosomal CpG island demethylation IDA
IDA: Inferred from direct assay
21496894 GOA
involved in retrotransposon silencing IDA
IDA: Inferred from direct assay
16527742 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21835787 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21835787 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOBEC3C Protein Structure

APOBEC_N

APOBEC_N: APOBEC-like N-terminal domain (19 - 185)

  • 0
  • 100
  • 190 a.a.
Protein Preferred Names Protein Names

DNA dC->dU-editing enzyme APOBEC-3C

  • apolipoprotein B editing enzyme catalytic polypeptide-like 3C

APOBEC3C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
APOBEC3C Q9NRW3 CHTOP Homo sapiens Q9Y3Y2-3
Validated Y2H
32296183
Intra
APOBEC3C Q9NRW3 CHTOP Homo sapiens Q9Y3Y2-3
Y2H Prey Pooling
32296183
Intra
APOBEC3C Q9NRW3 CHTOP Homo sapiens Q9Y3Y2-3
Y2H Array
32296183
Intra
APOBEC3C Q9NRW3 ZNF48 Homo sapiens Q96MX3
Anti Tag CoIP
33961781
Intra
APOBEC3C Q9NRW3 PRR3 Homo sapiens P79522
Y2H Prey Pooling
32296183
Intra
APOBEC3C Q9NRW3 PRR3 Homo sapiens P79522
Y2H Array
32296183
Intra
APOBEC3C Q9NRW3 TRIB3 Homo sapiens Q96RU7
Y2H Array
32296183
Intra
APOBEC3C Q9NRW3 TRIB3 Homo sapiens Q96RU7
Anti Tag CoIP
33961781
Intra
APOBEC3C Q9NRW3 TRIB3 Homo sapiens Q96RU7
Y2H Prey Pooling
32296183
Intra
APOBEC3C Q9NRW3 RBMX Homo sapiens P38159
Validated Y2H
25416956
Intra
APOBEC3C Q9NRW3 RBMX Homo sapiens P38159
Y2H Array
25416956
Intra
APOBEC3C Q9NRW3 RBMX Homo sapiens P38159
Y2H Prey Pooling
32296183
Intra
APOBEC3C Q9NRW3 RBMX Homo sapiens P38159
Y2H Array
32296183
Intra
APOBEC3C Q9NRW3 ZNF581 Homo sapiens Q9P0T4
Validated Y2H
32296183
Intra
APOBEC3C Q9NRW3 RBMY1A1 Homo sapiens P0DJD3
Validated Y2H
25416956
Intra
APOBEC3C Q9NRW3 RBMY1A1 Homo sapiens P0DJD3
Y2H Prey Pooling
25416956
Intra
APOBEC3C Q9NRW3 RBMY1F Homo sapiens Q15415
Validated Y2H
25416956
Intra
APOBEC3C Q9NRW3 RBMY1F Homo sapiens Q15415
Y2H Prey Pooling
32296183
Intra
APOBEC3C Q9NRW3 RBMY1F Homo sapiens Q15415
Y2H Array
32296183
Intra
APOBEC3C Q9NRW3 RBMY1F Homo sapiens Q15415
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Plantar Wart

  • Verruca Plantaris

  • Verrucae On Sole Of Foot

  • Mosaic Plantar Warts
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00837 APOBEC3C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120157 Vif-ElonginC interaction inhibitor 1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus APOBEC3C MGD MGI:1933111
Others APOBEC3C NCBI