Hmgb3 - high mobility group box 3 Gene

Also Known as Hmg4; Hmg2a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15354

Summary

Enables DNA binding activity and RNA binding activity. Acts upstream of or within negative regulation of B cell differentiation and negative regulation of myeloid cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; ear; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in syndromic microphthalmia 13. Orthologous to human HMGB3 (high mobility group box 3). [provided by Alliance of Genome Resources, Apr 2022]

Hmgb3 Products (11)

mRNA Protein Name
NM_001293623.2 NP_001280552.1 high mobility group protein B3 isoform 1
NM_001293624.2 NP_001280553.1 high mobility group protein B3 isoform 1
NM_001293625.2 NP_001280554.1 high mobility group protein B3 isoform 1
NM_001411295.1 NP_001398224.1 high mobility group protein B3 isoform 1
NM_001411296.1 NP_001398225.1 high mobility group protein B3 isoform 1
NM_001411299.1 NP_001398228.1 high mobility group protein B3 isoform 1
NM_001411300.1 NP_001398229.1 high mobility group protein B3 isoform 2
NM_001411301.1 NP_001398230.1 high mobility group protein B3 isoform 3
NM_001411302.1 NP_001398231.1 high mobility group protein B3 isoform 3
NM_001411303.1 NP_001398232.1 high mobility group protein B3 isoform 3
NM_008253.5 NP_032279.1 high mobility group protein B3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
19890330 MGI
enables RNA binding IDA
IDA: Inferred from direct assay
19890330 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of B cell differentiation IDA
IDA: Inferred from direct assay
12714519 MGI
acts upstream of or within negative regulation of myeloid cell differentiation IDA
IDA: Inferred from direct assay
12714519 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12714519 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

high mobility group protein B3

  • high mobility group protein 2a

  • high mobility group protein 4

  • high mobilty group protein 2A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06234 HMGB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17980 Hmgb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24451 Hmgb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmgb3 NCBI NCBI:3149