Hoxa11 - homeobox A11 Gene

Also Known as Hox-1.9; Hoxa-11

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15396

Summary

This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important in the development of the skeleton, limbs, and urogenital tract. Expression of this gene may be regulated by overlapping transcription from an adjacent locus on the opposite strand (GeneID: 15397). [provided by RefSeq, Mar 2013]

Hoxa11 Products (1)

mRNA Protein Name
NM_010450.3 NP_034580.1 homeobox protein Hox-A11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14973489 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
12869760 MGI
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
7789268 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IGI
IGI: Inferred from genetic interaction
11493536 MGI
acts upstream of or within cartilage development involved in endochondral bone morphogenesis IGI
IGI: Inferred from genetic interaction
14668414 MGI
acts upstream of cell development IGI
IGI: Inferred from genetic interaction
14668414 MGI
acts upstream of chondrocyte development IGI
IGI: Inferred from genetic interaction
14668414 MGI
acts upstream of chondrocyte differentiation IGI
IGI: Inferred from genetic interaction
14668414 MGI
acts upstream of or within developmental growth IGI
IGI: Inferred from genetic interaction
14668414 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: Inferred from genetic interaction
11493536 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
12869760 MGI
acts upstream of or within embryonic forelimb morphogenesis IGI
IGI: Inferred from genetic interaction
22916278 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
14668414 MGI
acts upstream of or within embryonic skeletal joint morphogenesis IGI
IGI: Inferred from genetic interaction
20978074 MGI
acts upstream of or within male gonad development IGI
IGI: Inferred from genetic interaction
23760953 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
7789268 MGI
involved in mesodermal cell fate specification IDA
IDA: Inferred from direct assay
17785448 MGI
acts upstream of or within metanephros development IGI
IGI: Inferred from genetic interaction
12050119 MGI
acts upstream of or within multicellular organism development IDA
IDA: Inferred from direct assay
11900456 MGI
acts upstream of or within organ induction IGI
IGI: Inferred from genetic interaction
12050119 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17785448 MGI
acts upstream of or within positive regulation of chondrocyte development IGI
IGI: Inferred from genetic interaction
14668414 MGI
acts upstream of or within positive regulation of chondrocyte differentiation IGI
IGI: Inferred from genetic interaction
14668414 MGI
acts upstream of or within proximal/distal pattern formation IGI
IGI: Inferred from genetic interaction
12869760 MGI
acts upstream of or within regulation of chondrocyte differentiation IGI
IGI: Inferred from genetic interaction
22916278 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
23760953 MGI
acts upstream of or within single fertilization IGI
IGI: Inferred from genetic interaction
23760953 MGI
acts upstream of or within single fertilization IMP
IMP: Inferred from mutant phenotype
7789268 MGI
acts upstream of or within skeletal system development IGI
IGI: Inferred from genetic interaction
12869760 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
7596412 MGI
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
23760953 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
7789268 MGI
acts upstream of or within uterus development IGI
IGI: Inferred from genetic interaction
23760953 MGI
acts upstream of or within uterus development IMP
IMP: Inferred from mutant phenotype
7789268 MGI
Cellular Component GO Annotation Evidence References Source
part of protein-DNA complex IDA
IDA: Inferred from direct assay
17785448 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
17785448 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
9343407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Hox-A11

  • homeo box A11

  • homeobox protein Hox-1.9

Hoxa11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Hoxa11 P31311 Gmnn Mus musculus O88513
Y2H
14973489
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06295 HOXA11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hoxa11 NCBI NCBI:3207