Hoxa11 - homeobox A11 Gene

Mus musculus

Also known as Hox-1.9; Hoxa-11

Gene ID: 15396 | Gene type: protein coding

About Hoxa11

Summary

This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important in the development of the skeleton, limbs, and urogenital tract. Expression of this gene may be regulated by overlapping transcription from an adjacent locus on the opposite strand (GeneID: 15397). [provided by RefSeq, Mar 2013]

Hoxa11 Products(1)

mRNA	Protein	Name
NM_010450.3	NP_034580.1	homeobox protein Hox-A11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14973489	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	12869760	MGI
acts upstream of or within bone development	IMP IMP: Inferred from mutant phenotype	7789268	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IGI IGI: Inferred from genetic interaction	11493536	MGI
acts upstream of or within cartilage development involved in endochondral bone morphogenesis	IGI IGI: Inferred from genetic interaction	14668414	MGI
acts upstream of cell development	IGI IGI: Inferred from genetic interaction	14668414	MGI
acts upstream of chondrocyte development	IGI IGI: Inferred from genetic interaction	14668414	MGI
acts upstream of chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	14668414	MGI
acts upstream of or within developmental growth	IGI IGI: Inferred from genetic interaction	14668414	MGI
acts upstream of or within dorsal/ventral pattern formation	IGI IGI: Inferred from genetic interaction	11493536	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	12869760	MGI
acts upstream of or within embryonic forelimb morphogenesis	IGI IGI: Inferred from genetic interaction	22916278	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	14668414	MGI
acts upstream of or within embryonic skeletal joint morphogenesis	IGI IGI: Inferred from genetic interaction	20978074	MGI
acts upstream of or within male gonad development	IGI IGI: Inferred from genetic interaction	23760953	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	7789268	MGI
involved in mesodermal cell fate specification	IDA IDA: Inferred from direct assay	17785448	MGI
acts upstream of or within metanephros development	IGI IGI: Inferred from genetic interaction	12050119	MGI
acts upstream of or within multicellular organism development	IDA IDA: Inferred from direct assay	11900456	MGI
acts upstream of or within organ induction	IGI IGI: Inferred from genetic interaction	12050119	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17785448	MGI
acts upstream of or within positive regulation of chondrocyte development	IGI IGI: Inferred from genetic interaction	14668414	MGI
acts upstream of or within positive regulation of chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	14668414	MGI
acts upstream of or within proximal/distal pattern formation	IGI IGI: Inferred from genetic interaction	12869760	MGI
acts upstream of or within regulation of chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	22916278	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	23760953	MGI
acts upstream of or within single fertilization	IGI IGI: Inferred from genetic interaction	23760953	MGI
acts upstream of or within single fertilization	IMP IMP: Inferred from mutant phenotype	7789268	MGI
acts upstream of or within skeletal system development	IGI IGI: Inferred from genetic interaction	12869760	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	7596412	MGI
acts upstream of or within spermatogenesis	IGI IGI: Inferred from genetic interaction	23760953	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	7789268	MGI
acts upstream of or within uterus development	IGI IGI: Inferred from genetic interaction	23760953	MGI
acts upstream of or within uterus development	IMP IMP: Inferred from mutant phenotype	7789268	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-DNA complex	IDA IDA: Inferred from direct assay	17785448	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	17785448	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	9343407	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein Hox-A11

homeo box A11

homeobox protein Hox-1.9

Hoxa11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Hoxa11	P31311	Gmnn	Mus musculus	O88513	Y2H	14973489

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06295	HOXA11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hoxa11	NCBI	NCBI:3207

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