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Hoxa13 - homeobox A13 Gene

Also Known as Hd; Hox-1.10

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15398

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including circulatory system development; endothelial cell differentiation; and reproductive structure development. Located in nucleus. Is expressed in several structures, including genitourinary system; intestine; limb; limb bud; and nervous system. Used to study hand-foot-genital syndrome. Human ortholog(s) of this gene implicated in Guttmacher syndrome and hand-foot-genital syndrome. Orthologous to human HOXA13 (homeobox A13). [provided by Alliance of Genome Resources, Apr 2022]

Hoxa13 Products (1)

mRNA	Protein	Name
NM_008264.1	NP_032290.1	homeobox protein Hox-A13

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	19168674	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	27706137	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16314414	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	15342482	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	27706137	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15617687	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18483557	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anatomical structure morphogenesis	IMP IMP: Inferred from mutant phenotype	12783783	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	10210434	MGI
acts upstream of or within artery morphogenesis	IMP IMP: Inferred from mutant phenotype	18483557	MGI
acts upstream of or within branching involved in prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	10210434	MGI
acts upstream of or within embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	15733672	MGI
acts upstream of or within endothelial cell fate specification	IMP IMP: Inferred from mutant phenotype	18483557	MGI
acts upstream of or within endothelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	18483557	MGI
acts upstream of or within inner ear development	IMP IMP: Inferred from mutant phenotype	18483557	MGI
acts upstream of or within male genitalia development	IMP IMP: Inferred from mutant phenotype	12783783	MGI
acts upstream of mesenchymal cell apoptotic process	IMP IMP: Inferred from mutant phenotype	12783783	MGI
acts upstream of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	12783783	MGI
acts upstream of or within positive regulation of mesenchymal cell apoptotic process	IMP IMP: Inferred from mutant phenotype	12783783	MGI
acts upstream of or within positive regulation of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	12783783	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16314414	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21829694	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18483557	MGI
acts upstream of or within regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	12783783	MGI
acts upstream of or within tissue homeostasis	IMP IMP: Inferred from mutant phenotype	18483557	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16314414	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	18483557	MGI
acts upstream of or within ventricular septum development	IMP IMP: Inferred from mutant phenotype	18483557	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	15617687	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
homeobox protein Hox-A13	homeobox protein Hox-1.10 hypodactyly

Hoxa13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Hoxa13	Q62424	Meis1	Mus musculus	Q60954-2	Anti Tag CoIP	15617687
Intra	Hoxa13	Q62424	Meis1	Mus musculus	Q60954-2	Y2H	15617687
Intra	Hoxa13	Q62424	Smad5	Mus musculus	P97454	Y2H	16087734

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06296	HOXA13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hoxa13	NCBI	NCBI:3209