2. Gene
  3. Hsd3b1 - hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Gene

Hsd3b1 - hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as D3Ertd383e; 3-beta-HSD I

Gene ID: 15492 | Gene type: protein coding

About Hsd3b1

Summary

Predicted to enable 3-beta-hydroxy-delta5-steroid dehydrogenase activity and steroid delta-isomerase activity. Predicted to be involved in several processes, including C21-steroid hormone metabolic process; hippocampus development; and response to corticosterone. Predicted to act upstream of or within steroid metabolic process. Located in mitochondrion. Is expressed in several structures, including endocrine gland; genitourinary system; liver; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]

Hsd3b1 Products(2)

mRNA Protein Name
NM_001304800.1 NP_001291729.1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
NM_008293.4 NP_032319.1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables steroid delta-isomerase activity IDA
IDA: Inferred from direct assay
1924345 MGI
Biological Process GO Annotation Evidence Reference Source
involved in androgen biosynthetic process IDA
IDA: Inferred from direct assay
1924345 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

3-beta-hydroxy-5-ene steroid dehydrogenase

3-beta-hydroxy-Delta(5)-steroid dehydrogenase

3-beta-hydroxysteroid 3-dehydrogenase

delta-5-3-ketosteroid isomerase

dihydrotestosterone oxidoreductase

steroid Delta-isomerase

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06401 HSD3B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd3b1 NCBI NCBI:3283