Hus1 - HUS1 checkpoint clamp component Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15574

Summary

This gene encodes a component of a cell cycle checkpoint complex that causes cell cycle arrest in response to bulky DNA lesions and DNA replication blockage. Together with the proteins Rad9 and Rad1, the encoded protein forms a heterotrimeric complex known as the 9-1-1 complex. Mice lacking the encoded protein develop spontaneous chromosomal abnormalities resulting in embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Hus1 Products (3)

mRNA	Protein	Name
NM_001303532.1	NP_001290461.1	checkpoint protein HUS1 isoform 2
NM_001303610.1	NP_001290539.1	checkpoint protein HUS1 isoform 3
NM_008316.5	NP_032342.1	checkpoint protein HUS1 isoform 1

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	12529385	MGI
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	11790307	MGI
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	16278671	MGI
involved in embryo development ending in birth or egg hatching	IMP IMP: Inferred from mutant phenotype	15919177	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	11790307	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	12529385	MGI
involved in regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	12676962	MGI
acts upstream of or within response to UV	IDA IDA: Inferred from direct assay	11790307	MGI
acts upstream of or within response to UV	IMP IMP: Inferred from mutant phenotype	12529385	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
checkpoint protein HUS1	Hus1 homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11232	NAB815	Inhibitor	/	Unkown
HY-RS06492	HUS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hus1	NCBI	NCBI:3364