Il6ra - interleukin 6 receptor, alpha Gene

Also Known as Il6r; CD126; IL-6R; IL-6RA; IL-6R-alpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16194

Summary

Enables interleukin-6 binding activity and interleukin-6 receptor activity. Involved in T-helper 17 cell lineage commitment and interleukin-6-mediated signaling pathway. Located in cell surface. Part of interleukin-6 receptor complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach Cancer. Orthologous to human IL6R (interleukin 6 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Il6ra Products (2)

mRNA Protein Name
NM_001310676.1 NP_001297605.1 interleukin-6 receptor subunit alpha isoform 2 precursor
NM_010559.3 NP_034689.2 interleukin-6 receptor subunit alpha isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables interleukin-6 receptor activity IDA
IDA: Inferred from direct assay
27893700 MGI
Biological Process GO Annotation Evidence References Source
involved in T-helper 17 cell lineage commitment IDA
IDA: Inferred from direct assay
27893700 MGI
acts upstream of or within interleukin-6-mediated signaling pathway IDA
IDA: Inferred from direct assay
1312474 MGI
involved in interleukin-6-mediated signaling pathway IDA
IDA: Inferred from direct assay
27893700 MGI
Cellular Component GO Annotation Evidence References Source
part of interleukin-6 receptor complex IDA
IDA: Inferred from direct assay
27893700 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-6 receptor subunit alpha

  • IL-6 receptor alpha chain

  • IL-6 receptor subunit alpha

  • IL-6R 1

  • IL-6R subunit alpha

Recombinant Il6ra Proteins

Cat. No. Product Name Accession Purity
HY-P72538 IL-6R alpha Protein, Mouse (HEK293, His) P22272 (L20-P364) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78852 IL-6R alpha Protein, Mouse (Biotinylated, HEK293, His-Avi) P22272 (L20-E357) ≥ 95%, as determined by reducing SDS-PAGE.

Il6ra Antibodies

Cat. No. Product Name Application Reactivity
HY-P89690 IL-6Rα Antibody (YA9034) WB, ICC/IF, IF-Tissue, IP, ELISA mouse, rat

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10284 S7 98.25% Phase 4

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06777 IL6R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23587 Il6r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990662 Sapelizumab Inhibitor 98.31% Unkown
HY-P990547 APX-007 Inhibitor / Unkown