Inppl1 - inositol polyphosphate phosphatase-like 1 Gene

Mus musculus

Also known as 51C; SHIP2

Gene ID: 16332 | Gene type: protein coding

About Inppl1

Summary

Predicted to enable SH2 domain binding activity; inositol-polyphosphate 5-phosphatase activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Acts upstream of or within several processes, including phosphatidylinositol biosynthetic process; response to insulin; and ruffle assembly. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; ear; respiratory system; and testis. Human ortholog(s) of this gene implicated in hypertension; obesity; and type 2 diabetes mellitus. Orthologous to human INPPL1 (inositol polyphosphate Phosphatase like 1). [provided by Alliance of Genome Resources, Apr 2022]

Inppl1 Products(6)

mRNA	Protein	Name
NM_001122739.2	NP_001116211.1	phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a
NM_001412588.1	NP_001399517.1	phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a
NM_001412589.1	NP_001399518.1	phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a
NM_001412590.1	NP_001399519.1	phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a
NM_001412591.1	NP_001399520.1	phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform b
NM_010567.3	NP_034697.2	phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14502564	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	28878342	MGI
acts upstream of or within apoptotic process	IDA IDA: Inferred from direct assay	28878342	MGI
acts upstream of or within apoptotic process	IGI IGI: Inferred from genetic interaction	28878342	MGI
acts upstream of or within cellular lipid metabolic process	IMP IMP: Inferred from mutant phenotype	15654325	MGI
acts upstream of or within gene expression	IGI IGI: Inferred from genetic interaction	28878342	MGI
acts upstream of or within glucose metabolic process	IMP IMP: Inferred from mutant phenotype	11343120	MGI
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	14502564	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15654325	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	28878342	MGI
acts upstream of or within phosphatidylinositol biosynthetic process	IMP IMP: Inferred from mutant phenotype	21624956	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	11343120	MGI
acts upstream of or within response to insulin	IMP IMP: Inferred from mutant phenotype	11343120	MGI
acts upstream of or within ruffle assembly	IMP IMP: Inferred from mutant phenotype	21624956	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14502564	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	14502564	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

INPPL-1	SH2 domain-containing inositol 5'-phosphatase 2
SH2 domain-containing inositol phosphatase 2	SHIP-2
ablSH3-binding protein	inositol polyphosphate phosphatase-like protein 1
protein 51C

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06834	INPPL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Inppl1	NCBI	NCBI:3636

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