Inppl1 - inositol polyphosphate phosphatase-like 1 Gene

Also Known as 51C; SHIP2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16332

Summary

Predicted to enable SH2 domain binding activity; inositol-polyphosphate 5-phosphatase activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Acts upstream of or within several processes, including phosphatidylinositol biosynthetic process; response to insulin; and ruffle assembly. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; ear; respiratory system; and testis. Human ortholog(s) of this gene implicated in hypertension; obesity; and type 2 diabetes mellitus. Orthologous to human INPPL1 (inositol polyphosphate Phosphatase like 1). [provided by Alliance of Genome Resources, Apr 2022]

Inppl1 Products (6)

mRNA Protein Name
NM_001122739.2 NP_001116211.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a
NM_001412588.1 NP_001399517.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a
NM_001412589.1 NP_001399518.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a
NM_001412590.1 NP_001399519.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a
NM_001412591.1 NP_001399520.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform b
NM_010567.3 NP_034697.2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14502564 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
28878342 MGI
acts upstream of or within apoptotic process IDA
IDA: Inferred from direct assay
28878342 MGI
acts upstream of or within apoptotic process IGI
IGI: Inferred from genetic interaction
28878342 MGI
acts upstream of or within cellular lipid metabolic process IMP
IMP: Inferred from mutant phenotype
15654325 MGI
acts upstream of or within gene expression IGI
IGI: Inferred from genetic interaction
28878342 MGI
acts upstream of or within glucose metabolic process IMP
IMP: Inferred from mutant phenotype
11343120 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
14502564 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
15654325 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
28878342 MGI
acts upstream of or within phosphatidylinositol biosynthetic process IMP
IMP: Inferred from mutant phenotype
21624956 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
11343120 MGI
acts upstream of or within response to insulin IMP
IMP: Inferred from mutant phenotype
11343120 MGI
acts upstream of or within ruffle assembly IMP
IMP: Inferred from mutant phenotype
21624956 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14502564 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
14502564 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

  • INPPL-1

  • SH2 domain-containing inositol 5'-phosphatase 2

  • SH2 domain-containing inositol phosphatase 2

  • SHIP-2

  • ablSH3-binding protein

  • inositol polyphosphate phosphatase-like protein 1

  • protein 51C

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06834 INPPL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Inppl1 NCBI NCBI:3636