Invs - inversin Gene

Also Known as inv; Nphp2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16348

Summary

Predicted to enable Calmodulin binding activity. Acts upstream of or within several processes, including animal organ development; epithelial cilium movement involved in determination of left/right asymmetry; and protein localization to ciliary inversin compartment. Located in ciliary base and ciliary inversin compartment. Is expressed in several structures, including adrenal gland; brain; gut gland; hemolymphoid system; and skeletal musculature. Used to study nephronophthisis 2 and tetralogy of Fallot. Human ortholog(s) of this gene implicated in nephronophthisis 2. Orthologous to human INVS (inversin). [provided by Alliance of Genome Resources, Apr 2022]

Invs Products (6)

mRNA Protein Name
NM_001281977.1 NP_001268906.1 inversin isoform 2
NM_001281978.1 NP_001268907.1 inversin isoform 3
NM_010569.4 NP_034699.3 inversin isoform 1
NM_001281977.1 NP_001268906.1 inversin isoform 2
NM_001281978.1 NP_001268907.1 inversin isoform 3
NM_010569.4 NP_034699.3 inversin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21565611 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within animal organ development IMP
IMP: Inferred from mutant phenotype
9771707 MGI
acts upstream of or within embryonic heart tube left/right pattern formation IMP
IMP: Inferred from mutant phenotype
9192865 MGI
acts upstream of or within epithelial cilium movement involved in determination of left/right asymmetry IMP
IMP: Inferred from mutant phenotype
10549278 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
9771707 MGI
acts upstream of or within pancreas development IMP
IMP: Inferred from mutant phenotype
9771707 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
9771707 MGI
acts upstream of or within protein localization to ciliary inversin compartment IMP
IMP: Inferred from mutant phenotype
29395339 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
29395339 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary base IDA
IDA: Inferred from direct assay
20169535 MGI
located in ciliary inversin compartment IDA
IDA: Inferred from direct assay
20169535 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inversin

  • inversion of embryo turning protein

  • nephrocystin 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5038 Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) 98.11% Unkown
HY-RS06860 INVS Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Invs NCBI NCBI:27130