Irx1 - Iroquois homeobox 1 Gene

Mus musculus

Gene ID: 16371 | Gene type: protein coding

About Irx1

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within proximal/distal pattern formation involved in metanephric nephron development and specification of loop of Henle identity. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; autopod; central nervous system; genitourinary system; and sensory organ. Orthologous to human IRX1 (iroquois homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Irx1 Products(1)

mRNA	Protein	Name
NM_010573.2	NP_034703.2	iroquois-class homeodomain protein IRX-1

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in metanephros development	IEP IEP: Inferred from expression pattern	17875669	MGI
involved in proximal/distal pattern formation involved in metanephric nephron development	IEP IEP: Inferred from expression pattern	17875669	MGI
involved in specification of loop of Henle identity	IEP IEP: Inferred from expression pattern	17875669	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

iroquois-class homeodomain protein IRX-1

Iroquois related homeobox 1	homeodomain protein IRXA1
iroquois homeobox protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06920	IRX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06922	IRX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Irx1	NCBI	NCBI:79192

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