SDE2 - SDE2 telomere maintenance homolog Gene

Also Known as C1orf55; dJ671D7.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 163859

About SDE2

This gene has 1 transcript (splice variant), 199 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 11.6), thyroid (RPKM 7.7) and 25 other tissues.

Summary

Enables damaged DNA binding activity. Involved in several processes, including cellular response to UV; mitotic G1 DNA damage checkpoint signaling; and protein ubiquitination. Located in several cellular components, including Golgi apparatus; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

SDE2 Products (1)

mRNA	Protein	Name
NM_152608.4	NP_689821.3	replication stress response regulator SDE2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables damaged DNA binding	IDA IDA: Inferred from direct assay	27906959	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24981860	GOA
enables snoRNA binding	IDA IDA: Inferred from direct assay	34365507	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to UV	IDA IDA: Inferred from direct assay	27906959	GOA
involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP IMP: Inferred from mutant phenotype	34365507	GOA
involved in mRNA cis splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	34365507	GOA
involved in mitotic G1 DNA damage checkpoint signaling	IDA IDA: Inferred from direct assay	27906959	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	27906959	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	27906959	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	34365507	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27906959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDE2 Protein Structure

Telomere_Sde2

Telomere_Sde2_2

0
100
200
300
400
451 a.a.

Protein Preferred Names	Protein Names
replication stress response regulator SDE2	UPF0667 protein C1orf55

SDE2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SDE2	Q6IQ49	HSPBAP1	Homo sapiens	Q96EW2	TAP	24981860
Intra	SDE2	Q6IQ49	HSPBAP1	Homo sapiens	Q96EW2	Anti Bait CoIP	24981860

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Meningeal Melanomatosis	Leptomeningeal Melanomatosis
Meningeal Melanoma	Melanoma Of The Leptomeninges Leptomeningeal Melanoma
Malignant Leptomeningeal Tumor	Malignant Leptomeningeal Tumour Malignant Tumor Of Leptomeninges Malignant Tumour Of Leptomeninges Malignant Leptomeningeal Neoplasm
Junctional Epidermolysis Bullosa	Epidermolysis Bullosa, Junctional Jeb Epidermolysis Bullosa Atrophicans Congenital Junctional Epidermolysis Bullosa Epidermolysis Bullosa Junctional Junctional Eb - [Epidermolysis Bullosa] Jeb - [Junctional Epidermolysis Bullosa] Lucidolytic Epidermolysis Bullosa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12586	SDE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SDE2	VGNC	VGNC:100135
Bos taurus	SDE2	VGNC	VGNC:34384
Mus musculus	SDE2	MGD	MGI:2384788
Felis catus	SDE2	VGNC	VGNC:64948
Rattus norvegicus	SDE2	RGD	RGD:1305572
Canis familiaris	SDE2	VGNC	VGNC:45946
Others	SDE2	NCBI