Itgb1bp1 - integrin beta 1 binding protein 1 Gene

Also Known as Icap1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16413

Summary

Enables protein kinase binding activity. Involved in several processes, including Integrin activation; positive regulation of stress fiber assembly; and regulation of cell-substrate adhesion. Located in several cellular components, including cytoskeleton; lamellipodium; and ruffle. Is expressed in left lung and right lung. Orthologous to human ITGB1BP1 (Integrin subunit beta 1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Itgb1bp1 Products (2)

mRNA	Protein	Name
NM_001355609.1	NP_001342538.1	integrin beta-1-binding protein 1
NM_008403.5	NP_032429.1	integrin beta-1-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinase binding	IPI IPI: Inferred from physical interaction	17654484	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16741948	MGI
enables protein kinase binding	IDA IDA: Inferred from direct assay	16741948	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in integrin activation	IDA IDA: Inferred from direct assay	18227284	MGI
involved in myoblast migration	IMP IMP: Inferred from mutant phenotype	17654484	MGI
involved in negative regulation of cell adhesion involved in substrate-bound cell migration	IDA IDA: Inferred from direct assay	18227284	MGI
involved in negative regulation of fibroblast migration	IDA IDA: Inferred from direct assay	18227284	MGI
involved in negative regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	18227284	MGI
involved in negative regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	18227284	MGI
involved in positive regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	17654484	MGI
involved in positive regulation of protein targeting to membrane	IDA IDA: Inferred from direct assay	16741948	MGI
involved in positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	17654484	MGI
involved in receptor clustering	IDA IDA: Inferred from direct assay	18227284	MGI
involved in regulation of cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	18227284	MGI
involved in regulation of integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	17654484	MGI
involved in regulation of integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18227284	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoskeleton	IDA IDA: Inferred from direct assay	16741948	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	16741948	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16741948	MGI
located in ruffle	IDA IDA: Inferred from direct assay	16741948	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
integrin beta-1-binding protein 1	bodenin integrin cytoplasmic domain-associated protein 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06964	ITGB1BP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itgb1bp1	NCBI	NCBI:9270