Itgb5 - integrin beta 5 Gene

Also Known as [b]5; [b]-5; [b]5A; [b]5B; beta5; ESTM23; beta-5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16419

Summary

Enables Integrin binding activity. Involved in integrin-mediated signaling pathway; stress fiber assembly; and transforming growth factor beta receptor signaling pathway. Located in cell leading edge; focal adhesion; and glutamatergic synapse. Is integral component of synaptic membrane. Part of Integrin alphav-beta5 complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Orthologous to human ITGB5 (Integrin subunit beta 5). [provided by Alliance of Genome Resources, Apr 2022]

Itgb5 Products (3)

mRNA Protein Name
NM_001145884.2 NP_001139356.1 integrin beta-5 isoform 1 precursor
NM_001405063.1 NP_001391992.1 integrin beta-5 isoform 3
NM_010580.3 NP_034710.2 integrin beta-5 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IPI
IPI: Inferred from physical interaction
8601592 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24997346 MGI
Biological Process GO Annotation Evidence References Source
involved in integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
24036928 MGI
involved in stress fiber assembly IMP
IMP: Inferred from mutant phenotype
24036928 MGI
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24036928 MGI
Cellular Component GO Annotation Evidence References Source
located in cell leading edge IDA
IDA: Inferred from direct assay
18794329 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
18794329 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16467530 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
16467530 MGI
part of integrin alphav-beta5 complex IDA
IDA: Inferred from direct assay
20826760 MGI
is active in synaptic membrane IDA
IDA: Inferred from direct assay
16467530 MGI
is active in synaptic membrane IEP
IEP: Inferred from expression pattern
16467530 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin beta-5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18068 Itgb5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06969 ITGB5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24543 Itgb5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itgb5 NCBI NCBI:3693