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ITGB5 - integrin subunit beta 5 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3693

About ITGB5

Cytogenetic location: 3q21.2 Genomic coordinates (GRCh38): 3:124,761,948-124,901,418 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 8 paralogues. Ubiquitous expression in placenta (RPKM 40.4), gall bladder (RPKM 34.0) and 24 other tissues.

Summary

This gene encodes a beta subunit of Integrin, which can combine with different alpha chains to form a variety of Integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 Integrin is involved in adhesion to Vitronectin. [provided by RefSeq, Aug 2017]

ITGB5 Products (4)

mRNA	Protein	Name
NM_001354764.2	NP_001341693.1	integrin beta-5 isoform b
NM_001354765.1	NP_001341694.1	integrin beta-5 isoform b
NM_001354766.2	NP_001341695.1	integrin beta-5 isoform c
NM_002213.5	NP_002204.2	integrin beta-5 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	1694173	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	26934001	GOA
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	24036928	GOA
involved in endodermal cell differentiation	IEP IEP: Inferred from expression pattern	23154389	GOA
involved in epithelial cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	24036928	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24036928	GOA
involved in stress fiber assembly	IMP IMP: Inferred from mutant phenotype	24036928	GOA
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24036928	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	7525578	GOA
part of integrin alphav-beta5 complex	IDA IDA: Inferred from direct assay	25063885	GOA
part of integrin alphav-beta5 complex	IPI IPI: Inferred from physical interaction	1694173	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGB5 Protein Structure

Integrin_beta

Integrin_B_tail

Integrin_b_cyt

0
200
400
600
799 a.a.

Protein Preferred Names	Protein Names
integrin beta-5	testis secretory sperm-binding protein Li 217p

ITGB5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ITGB5	P18084	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	ITGB5	P18084	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	ITGB5	P18084	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	32296183
Intra	ITGB5	P18084	KRTAP10-9	Homo sapiens	P60411	Y2H Array	32296183
Intra	ITGB5	P18084	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	32296183
Intra	ITGB5	P18084	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	ITGB5	P18084	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	ITGB5	P18084	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Cross	ITGB5	P18084	Myo7a	Mus musculus	P97479	Pull Down	24997346
Intra	ITGB5	P18084	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	ITGB5	P18084	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	ITGB5	P18084	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	ITGB5	P18084	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	ITGB5	P18084	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	ITGB5	P18084	KRTAP5-7	Homo sapiens	Q6L8G8	Validated Y2H	32296183
Intra	ITGB5	P18084	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	ITGB5	P18084	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	ITGB5	P18084	ANGPTL4	Homo sapiens	Q9BY76	PLA	21397862
Intra	ITGB5	P18084	ANGPTL4	Homo sapiens	Q9BY76	SPR	21397862
Intra	ITGB5	P18084	MYO10	Homo sapiens	Q9HD67	Pull Down	21642953
Intra	ITGB5	P18084	MYO10	Homo sapiens	Q9HD67	Competition Binding	21642953
Intra	ITGB5	P18084	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	ITGB5	P18084	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	ITGB5	P18084	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	ITGB5	P18084	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	ITGB5	P18084	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	ITGB5	P18084	FRMD5	Homo sapiens	Q7Z6J6	Pull Down	25448675
Intra	ITGB5	P18084	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	ITGB5	P18084	FHL3	Homo sapiens	Q13643	Validated Y2H	32296183
Intra	ITGB5	P18084	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	EFEMP2	Homo sapiens	O95967	Y2H Array	32296183
Intra	ITGB5	P18084	EFEMP2	Homo sapiens	O95967	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183
Intra	ITGB5	P18084	APPBP2	Homo sapiens	Q92624	Validated Y2H	32296183
Intra	ITGB5	P18084	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Array	32296183
Intra	ITGB5	P18084	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Prey Pooling	32296183
Intra	ITGB5	P18084	KRTAP3-2	Homo sapiens	Q9BYR7	Validated Y2H	32296183
Intra	ITGB5	P18084	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	ITGB5	P18084	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	ITGB5	P18084	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ITGB5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77720	Integrin alpha V beta 5 Protein, Human (HEK293, His-Avi)	P06756-1 (F31-V992)&P18084 (G24-N719)	≥ 95%, as determined by Bis-Tris PAGE.

ITGB5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83363	Integrin beta 5 Antibody (YA3108)	WB	Human, Hamster, Rat
HY-P83363A	Integrin beta 5 Antibody (YA3108)(PBS only)	WB	Human, Hamster, Rat
HY-P84144	Integrin beta 5 Antibody (YA3841)	ICC/IF, FC, ELISA	Human
HY-P84144A	Integrin beta 5 Antibody (YA3841)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Villous Adenocarcinoma
Osteopetrosis, Autosomal Dominant 2	OPTA2 Autosomal Dominant Osteopetrosis 2 Osteopetrosis Autosomal Dominant Type 2 Osteopetrosis, Autosomal Dominant, Type Ii Albers-Schonberg Osteopetrosis Autosomal Dominant Albers-Schonberg Disease Osteopetrosis Marble Bones, Autosomal Dominant Osteosclerosis Fragilis Generalisata Albers-Schonberg Disease, Autosomal Dominant Autosomal Dominant Osteopetrosis Type Ii Albers-Schönberg Osteopetrosis Autosomal Dominant Osteopetrosis Type 2 Marble Disease Autosomal Dominant Osteopetrosis, Autosomal Dominant, Type 2
Luminal Breast Carcinoma A	Breast Tumor Luminal Luminal A Breast Carcinoma Luminal Breast Cancer
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Familial Thyroid Dyshormonogenesis	Thyroid Dyshormonogenesis Familial Dyshormonogenetic Goiter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS18068	Itgb5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06969	ITGB5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24543	Itgb5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ITGB5	VGNC	VGNC:73788
Canis familiaris	ITGB5	VGNC	VGNC:42140
Felis catus	ITGB5	VGNC	VGNC:67854
Bos taurus	ITGB5	VGNC	VGNC:30330
Rattus norvegicus	ITGB5	RGD	RGD:628869
Mus musculus	ITGB5	MGD	MGI:96614
Others	ITGB5	NCBI