FRMD5 - FERM domain containing 5 Gene

Also Known as NEDEMA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84978

About FRMD5

Cytogenetic location: 15q15.3 Genomic coordinates (GRCh38): 15:43,870,764-44,199,473 (from NCBI)

This gene has 12 transcripts (splice variants), 306 orthologues and 10 paralogues. Biased expression in brain (RPKM 6.9), heart (RPKM 4.6) and 4 other tissues.

Summary

Enables Integrin binding activity and protein kinase binding activity. Involved in negative regulation of cell motility; positive regulation of cell adhesion; and regulation of cell migration. Located in adherens junction. [provided by Alliance of Genome Resources, Apr 2022]

FRMD5 Products (7)

mRNA Protein Name
NM_001286490.2 NP_001273419.1 FERM domain-containing protein 5 isoform 3
NM_001286491.2 NP_001273420.1 FERM domain-containing protein 5 isoform 4
NM_001322949.2 NP_001309878.1 FERM domain-containing protein 5 isoform 6
NM_001322950.2 NP_001309879.1 FERM domain-containing protein 5 isoform 7
NM_001322951.2 NP_001309880.1 FERM domain-containing protein 5 isoform 8
NM_001411124.1 NP_001398053.1 FERM domain-containing protein 5 isoform 9
NM_032892.5 NP_116281.2 FERM domain-containing protein 5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IDA
IDA: Inferred from direct assay
25448675 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22846708 GOA
enables protein kinase binding IDA
IDA: Inferred from direct assay
25448675 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell motility IMP
IMP: Inferred from mutant phenotype
25448675 GOA
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
25448675 GOA
involved in regulation of cell migration IMP
IMP: Inferred from mutant phenotype
22846708 GOA
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
22846708 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FRMD5 Protein Structure

FERM_N

FERM_N: FERM N-terminal domain (21 - 98)

FERM_M

FERM_M: FERM central domain (100 - 210)

FERM_C

FERM_C: FERM C-terminal PH-like domain (216 - 300)

FA

FA: FERM adjacent (FA) (308 - 353)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 570 a.a.
Protein Preferred Names Protein Names

FERM domain-containing protein 5

FRMD5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FRMD5 Q7Z6J6 ITGB5 Homo sapiens P18084
Anti Tag CoIP
25448675
Intra
FRMD5 Q7Z6J6 CTNND1 Homo sapiens O60716
Anti Bait CoIP
22846708
Intra
FRMD5 Q7Z6J6 CTNND1 Homo sapiens O60716
IF
22846708
Intra
FRMD5 Q7Z6J6 CTNND1 Homo sapiens O60716
Anti Tag CoIP
22846708
Intra
FRMD5 Q7Z6J6 ROCK1 Homo sapiens Q13464
Anti Bait CoIP
25448675
Intra
FRMD5 Q7Z6J6 ROCK1 Homo sapiens Q13464
Anti Tag CoIP
25448675
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05103 FRMD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21576 Frmd5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28094 Frmd5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FRMD5 VGNC VGNC:29116
Canis familiaris FRMD5 VGNC VGNC:40982
Macaca mulatta FRMD5 VGNC VGNC:72797
Felis catus FRMD5 VGNC VGNC:62362
Rattus norvegicus FRMD5 RGD RGD:1561554
Mus musculus FRMD5 MGD MGI:2442557
Others FRMD5 NCBI