2. Gene
  3. Itih1 - inter-alpha trypsin inhibitor, heavy chain 1 Gene

Itih1 - inter-alpha trypsin inhibitor, heavy chain 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Intin1; Itih-1; ITI-HC1

Gene ID: 16424 | Gene type: protein coding

About Itih1

Summary

This gene encodes a heavy chain of inter-alpha trypsin inhibitor (IaI) family of plasma serine Protease Inhibitors. IaI proteins are protein-glycosaminoglycan-protein complexes comprised of two heavy chains and a light chain. The encoded protein covalently associates with the light chain via a chondroitin sulfate moiety. Intravenous administration of the encoded protein improved survival of mice after Infection with Escherichia coli. This gene is located adjacent to two Other IaI heavy chain genes. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature protein. [provided by RefSeq, Oct 2015]

Itih1 Products(2)

mRNA Protein Name
NM_001306078.1 NP_001293007.1 inter-alpha-trypsin inhibitor heavy chain H1 isoform 2 precursor
NM_008406.3 NP_032432.2 inter-alpha-trypsin inhibitor heavy chain H1 isoform 1 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17675295 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within extracellular matrix organization IDA
IDA: Inferred from direct assay
17675295 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
17675295 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inter-alpha-trypsin inhibitor heavy chain H1

inter-alpha (globulin) inhibitor, H1 polypeptide

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06974 ITIH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itih1 NCBI NCBI:3697