Itsn1 - intersectin 1 (SH3 domain protein 1A) Gene

Also Known as Ese1; Itsn; Ehsh1; Sh3p17

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16443

Summary

Enables kinase activator activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within negative regulation of neuron apoptotic process; positive regulation of protein kinase B signaling; and small GTPase mediated signal transduction. Located in several cellular components, including calyx of Held; clathrin-coated pit; and lamellipodium. Is active in presynaptic endocytic zone. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human ITSN1 (intersectin 1). [provided by Alliance of Genome Resources, Apr 2022]

Itsn1 Products (3)

mRNA Protein Name
NM_001110275.1 NP_001103745.1 intersectin-1 isoform 2
NM_001110276.1 NP_001103746.1 intersectin-1 isoform 3
NM_010587.2 NP_034717.2 intersectin-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kinase activator activity IDA
IDA: Inferred from direct assay
17875942 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11744688 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
17875942 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
17875942 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
17875942 MGI
acts upstream of or within small GTPase-mediated signal transduction IDA
IDA: Inferred from direct assay
11744688 MGI
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
18676989 MGI
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
18676989 MGI
Cellular Component GO Annotation Evidence References Source
is active in calyx of Held IDA
IDA: Inferred from direct assay
23633571 MGI
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
26437238 MGI
located in endocytic vesicle IDA
IDA: Inferred from direct assay
17875942 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
11744688 MGI
is active in presynaptic endocytic zone IDA
IDA: Inferred from direct assay
23633571 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intersectin-1

  • EH and SH3 domains protein 1

  • Eh domain, SH3 domain regulator of endocytosis 1

  • intersectin (SH3 domain protein 1A)

  • intersectin-L

Itsn1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Itsn1 Q9Z0R4 Dennd1a Mus musculus Q8K382
Anti Bait CoIP
17182770
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06997 ITSN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itsn1 NCBI NCBI:6453