Itsn1 - intersectin 1 (SH3 domain protein 1A) Gene

Mus musculus

Also known as Ese1; Itsn; Ehsh1; Sh3p17

Gene ID: 16443 | Gene type: protein coding

About Itsn1

Summary

Enables kinase activator activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within negative regulation of neuron apoptotic process; positive regulation of protein kinase B signaling; and small GTPase mediated signal transduction. Located in several cellular components, including calyx of Held; clathrin-coated pit; and lamellipodium. Is active in presynaptic endocytic zone. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human ITSN1 (intersectin 1). [provided by Alliance of Genome Resources, Apr 2022]

Itsn1 Products(3)

mRNA	Protein	Name
NM_001110275.1	NP_001103745.1	intersectin-1 isoform 2
NM_001110276.1	NP_001103746.1	intersectin-1 isoform 3
NM_010587.2	NP_034717.2	intersectin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase activator activity	IDA IDA: Inferred from direct assay	17875942	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11744688	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17875942	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17875942	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	17875942	MGI
acts upstream of or within small GTPase-mediated signal transduction	IDA IDA: Inferred from direct assay	11744688	MGI
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	18676989	MGI
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	18676989	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in calyx of Held	IDA IDA: Inferred from direct assay	23633571	MGI
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	26437238	MGI
located in endocytic vesicle	IDA IDA: Inferred from direct assay	17875942	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	11744688	MGI
is active in presynaptic endocytic zone	IDA IDA: Inferred from direct assay	23633571	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

intersectin-1

EH and SH3 domains protein 1	Eh domain, SH3 domain regulator of endocytosis 1
intersectin (SH3 domain protein 1A)	intersectin-L

Itsn1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Itsn1	Q9Z0R4	Dennd1a	Mus musculus	Q8K382	Anti Bait CoIP	17182770

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06997	ITSN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itsn1	NCBI	NCBI:6453

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