APOBEC3H - apolipoprotein B mRNA editing enzyme catalytic subunit 3H Gene

Also Known as A3H; ARP10; ARP-10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 164668

About APOBEC3H

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,097,244-39,104,067 (from NCBI)

This gene has 7 transcripts (splice variants), 88 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 1.2), colon (RPKM 1.0) and 22 other tissues.

Summary

This gene encodes a member of the Apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 Infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

APOBEC3H Products (4)

mRNA Protein Name
NM_001166002.3 NP_001159474.2 DNA dC->dU-editing enzyme APOBEC-3H isoform SV-182
NM_001166003.3 NP_001159475.2 DNA dC->dU-editing enzyme APOBEC-3H isoform SV-200
NM_001166004.3 NP_001159476.2 DNA dC->dU-editing enzyme APOBEC-3H isoform SV-154
NM_181773.5 NP_861438.3 DNA dC->dU-editing enzyme APOBEC-3H isoform SV-183

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytidine deaminase activity IDA
IDA: Inferred from direct assay
16571802 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22915799 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA cytosine deamination IDA
IDA: Inferred from direct assay
16571802 GOA
involved in clearance of foreign intracellular DNA IDA
IDA: Inferred from direct assay
20062055 GOA
involved in defense response to virus IDA
IDA: Inferred from direct assay
21835787 GOA
involved in negative regulation by host of viral genome replication IMP
IMP: Inferred from mutant phenotype
18827027 GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA
IDA: Inferred from direct assay
18779051 GOA
involved in retrotransposon silencing IDA
IDA: Inferred from direct assay
18779051 GOA
involved in retrotransposon silencing IMP
IMP: Inferred from mutant phenotype
18827027 GOA
Cellular Component GO Annotation Evidence References Source
located in P-body IDA
IDA: Inferred from direct assay
22915799 GOA
is active in cytoplasm IDA
IDA: Inferred from direct assay
29290613 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
18779051 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18779051 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOBEC3H Protein Structure

APOBEC_N

APOBEC_N: APOBEC-like N-terminal domain (23 - 172)

  • 0
  • 100
  • 200 a.a.
Protein Preferred Names Protein Names

DNA dC->dU-editing enzyme APOBEC-3H

  • APOBEC-related protein 10

Related Diseases

Diseases Alias
Plantar Wart

  • Verruca Plantaris

  • Verrucae On Sole Of Foot

  • Mosaic Plantar Warts
Human Immunodeficiency Virus Type 1

  • Aids

  • Hiv/Aids

  • Aids, Delayed/Rapid Progression To

  • Hiv-1, Susceptibility To

  • Hiv-1 Viremia, Susceptibility To

  • Human Immunodeficiency Virus Type 1, Susceptibility To

  • Hiv-1

  • Aids, Slow Progression To

  • Rapid Progression To Aids From Hiv1 Infection

  • Hiv1 Infection, Resistance To

  • Hiv1 Infection

  • Hiv-1 Viremia

  • Aids, Resistance To

  • Aids, Rapid Progression To

  • Hiv/Aids, Susceptibility To

  • Hiv-1, Resistance To

  • Hiv1, Resistance To

  • Hiv1

  • Hiv-1 Disease, Delayed Progression Of

  • Hiv-1 Disease, Rapid Progression Of

  • Hiv Infection, Resistance To

  • Hiv Type 1, Susceptibility To

  • Hiv Type 1

  • Hiv-1 Infection

  • Human Immunodeficiency Virus I Infection

  • Acquired Immunodeficiency Syndrome

  • Hiv-Infection/Aids
Bone Giant Cell Sarcoma

  • Giant Cell Sarcoma Of The Bone

  • Giant Cell Tumor Of Bone, Malignant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00841 APOBEC3H Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus APOBEC3H VGNC VGNC:108124
Macaca mulatta APOBEC3H VGNC VGNC:69894
Rattus norvegicus APOBEC3H RGD RGD:1307800
Others APOBEC3H NCBI