Kcnj11 - potassium inwardly rectifying channel, subfamily J, member 11 Gene

Also Known as mBIR; Kir6.2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16514

Summary

Enables ATP binding activity; ATP-activated inward rectifier Potassium Channel activity; and ankyrin binding activity. Involved in potassium ion import across plasma membrane. Located in T-tubule. Part of inward rectifying Potassium Channel. Is expressed in several structures, including brain; cardiovascular system; gut; skeletal muscle tissue; and testis. Used to study permanent neonatal diabetes mellitus. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 2 and glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj11 Products (3)

mRNA	Protein	Name
NM_001204411.2	NP_001191340.1	ATP-sensitive inward rectifier potassium channel 11 isoform 2
NM_001412604.1	NP_001399533.1	ATP-sensitive inward rectifier potassium channel 11 isoform 3 precursor
NM_010602.4	NP_034732.1	ATP-sensitive inward rectifier potassium channel 11 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12860923	MGI
enables ATP-activated inward rectifier potassium channel activity	IDA IDA: Inferred from direct assay	8630239	MGI
enables ankyrin binding	IPI IPI: Inferred from physical interaction	20610380	MGI
enables inward rectifier potassium channel activity	IDA IDA: Inferred from direct assay	7502040	MGI
enables inward rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	16924481	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9488482	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within CAMKK-AMPK signaling cascade	IMP IMP: Inferred from mutant phenotype	24498880	MGI
acts upstream of or within action potential	IGI IGI: Inferred from genetic interaction	16501027	MGI
acts upstream of or within action potential	IMP IMP: Inferred from mutant phenotype	23624089	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	24498880	MGI
acts upstream of or within cellular response to nutrient levels	IMP IMP: Inferred from mutant phenotype	23624089	MGI
acts upstream of or within determination of adult lifespan	IGI IGI: Inferred from genetic interaction	16501027	MGI
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	16924481	MGI
involved in potassium ion import across plasma membrane	IDA IDA: Inferred from direct assay	8630239	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	17445233	MGI
acts upstream of or within response to ischemia	IMP IMP: Inferred from mutant phenotype	24498880	MGI
acts upstream of or within response to resveratrol	IMP IMP: Inferred from mutant phenotype	24498880	MGI
acts upstream of or within response to stress	IGI IGI: Inferred from genetic interaction	16501027	MGI
acts upstream of or within ventricular cardiac muscle tissue development	IGI IGI: Inferred from genetic interaction	16501027	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in T-tubule	IDA IDA: Inferred from direct assay	20610380	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	18434629	MGI
part of inward rectifying potassium channel	IDA IDA: Inferred from direct assay	8630239	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	7502040	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16085792	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ATP-sensitive inward rectifier potassium channel 11	inward rectifier K(+) channel Kir6.2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07138	KCNJ11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnj11	NCBI	NCBI:3767