Kifap3 - kinesin-associated protein 3 Gene

Mus musculus

Also known as KAP3; SMAP; KAP-3

Gene ID: 16579 | Gene type: protein coding

About Kifap3

Summary

The protein encoded by this gene is the non-motor subunit of kinesin-2 complex, and forms a heterotrimer with two members of the Kinesin superfamily of proteins that together form a microtubule plus-end directed translocator that plays an important role in intracellular transport, Mitosis, and cell-cell adhesion. This protein contains multiple armadillo repeats involved in protein binding, and may serve as an adaptor to regulate binding of cargo with the motor proteins. Conditional disruption of this gene in mouse neural precursor cells caused a tumor-like phenotype and defective organization of the neuroepithelium thought to be the result of altered N-Cadherin subcellular localization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Kifap3 Products(2)

mRNA	Protein	Name
NM_001305643.1	NP_001292572.1	kinesin-associated protein 3 isoform KAP3A
NM_010629.3	NP_034759.1	kinesin-associated protein 3 isoform KAP3B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables intraciliary transport particle B binding	IDA IDA: Inferred from direct assay	12821668	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15834408	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in anterograde dendritic transport of neurotransmitter receptor complex	IDA IDA: Inferred from direct assay	31746486	MGI
involved in anterograde dendritic transport of neurotransmitter receptor complex	IMP IMP: Inferred from mutant phenotype	31746486	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	10793158	MGI
acts upstream of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	10793158	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15834408	MGI
involved in microtubule-based process	IPI IPI: Inferred from physical interaction	8710890	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10793158	MGI
acts upstream of or within negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	10793158	MGI
acts upstream of or within negative regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15834408	MGI
acts upstream of or within negative regulation of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	10793158	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15834408	MGI
acts upstream of or within positive regulation of calcium-dependent cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	15834408	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	15834408	MGI
acts upstream of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	10793158	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19384852	MGI
located in axoneme	IDA IDA: Inferred from direct assay	19384852	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	19384852	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19384852	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	31746486	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	31746486	MGI
part of kinesin II complex	IDA IDA: Inferred from direct assay	19384852	MGI
part of kinesin II complex	IPI IPI: Inferred from physical interaction	8710890	MGI
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	19384852	MGI
located in periciliary membrane compartment	IDA IDA: Inferred from direct assay	19384852	MGI
located in photoreceptor connecting cilium	IDA IDA: Inferred from direct assay	19384852	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	19384852	MGI
located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	19384852	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	31746486	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

kinesin-associated protein 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07297	KIFAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kifap3	NCBI	NCBI:22920

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