Klf12 - Kruppel-like factor 12 Gene

Also Known as AP-2rep; 2700063E05Rik; B130052C06Rik; D530033K05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16597

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human KLF12 (Kruppel like factor 12). [provided by Alliance of Genome Resources, Apr 2022]

Klf12 Products (2)

mRNA Protein Name
NM_001411709.1 NP_001398638.1 Krueppel-like factor 12
NM_010636.4 NP_034766.2 Krueppel-like factor 12

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
9858544 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16615998 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
9858544 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9858544 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20599664 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9858544 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16615998 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9858544 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Krueppel-like factor 12

  • transcriptional repressor AP-2rep

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07333 KLF12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Klf12 NCBI NCBI:11278