TRIM60 - tripartite motif containing 60 Gene

Also Known as RNF33; RNF129

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 166655

About TRIM60

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:165,031,999-165,041,749 (from NCBI)

This gene has 5 transcripts (splice variants), 37 orthologues and 80 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Pseudogenes of this gene are located on more than six chromosomes including chromosome 4. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

TRIM60 Products (2)

mRNA	Protein	Name
NM_001258025.2	NP_001244954.1	tripartite motif-containing protein 60
NM_152620.3	NP_689833.1	tripartite motif-containing protein 60

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables SUMO-ubiquitin ligase activity	IDA IDA: Inferred from direct assay	33184450	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	33184450	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM60 Protein Structure

zf-C3HC4_4

zf-B_box

PRY

SPRY

0
100
200
300
400
471 a.a.

Protein Preferred Names	Protein Names
tripartite motif-containing protein 60	ring finger protein 129

TRIM60 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM60	Q495X7	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	TRIM60	Q495X7	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	TRIM60	Q495X7	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome	Glomerulonephritis With Sparse Hair And Telangiectases Telangiectatic Membranoproliferative Glomerulonephritis HLTRS Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome Hlt-Renal Defect Syndrome Glomerulonephritis Sparse Hair Telangiectases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15061	TRIM60 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRIM60	VGNC	VGNC:80069
Mus musculus	TRIM60	MGD	MGI:2387430
Rattus norvegicus	TRIM60	RGD	RGD:2324264
Macaca mulatta	TRIM60	VGNC	VGNC:100286
Others	TRIM60	NCBI