Krt16 - keratin 16 Gene

Also Known as K16; CK-16; Krt1-16

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16666

Summary

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin and acts as an innate immune system effector, promoting the inflammatory response upon breach of the skin barrier. Defects in this gene are a cause of pachyonychia congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Krt16 Products (2)

mRNA Protein Name
NM_001313958.1 NP_001300887.1 keratin, type I cytoskeletal 16 isoform 1
NM_008470.1 NP_032496.1 keratin, type I cytoskeletal 16 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16702408 MGI
enables structural constituent of cytoskeleton IDA
IDA: Inferred from direct assay
12445204 MGI
Biological Process GO Annotation Evidence References Source
involved in establishment of skin barrier IMP
IMP: Inferred from mutant phenotype
24218583 MGI
involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
24218583 MGI
involved in innate immune response IMP
IMP: Inferred from mutant phenotype
24218583 MGI
acts upstream of or within intermediate filament cytoskeleton organization IDA
IDA: Inferred from direct assay
12445204 MGI
involved in keratinization IDA
IDA: Inferred from direct assay
11029038 MGI
involved in keratinocyte differentiation IDA
IDA: Inferred from direct assay
11029038 MGI
involved in keratinocyte migration IDA
IDA: Inferred from direct assay
11029038 MGI
involved in morphogenesis of an epithelium IMP
IMP: Inferred from mutant phenotype
24218583 MGI
Cellular Component GO Annotation Evidence References Source
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in intermediate filament IDA
IDA: Inferred from direct assay
12445204 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratin, type I cytoskeletal 16

  • cytokeratin-16

  • keratin complex 1, acidic, gene 16

  • keratin intermediate filament 16a

  • keratin intermediate filament 16b

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07439 KRT16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Krt16 NCBI NCBI:3868