Krt6a - keratin 6A Gene

Also Known as K6A; MK6a; CK-6A; K6[a]; mK6[a]; Krt2-6a; Krt2-6c; 2310016L08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16687

Summary

Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; and wound healing. Acts upstream of or within Wnt signaling pathway; intermediate filament organization; and keratinization. Predicted to be located in keratin filament. Is expressed in alimentary system; epithelium; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in pachyonychia congenita. Orthologous to several human genes including KRT6A (keratin 6A). [provided by Alliance of Genome Resources, Apr 2022]

Krt6a Products (1)

mRNA Protein Name
NM_008476.3 NP_032502.3 keratin, type II cytoskeletal 6A

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within Wnt signaling pathway IDA
IDA: Inferred from direct assay
19056892 MGI
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
IMP: Inferred from mutant phenotype
23006328 MGI
involved in defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
23006328 MGI
acts upstream of or within intermediate filament organization IGI
IGI: Inferred from genetic interaction
15601842 MGI
acts upstream of or within keratinization IGI
IGI: Inferred from genetic interaction
15601842 MGI
acts upstream of or within morphogenesis of an epithelium IGI
IGI: Inferred from genetic interaction
15601842 MGI
involved in morphogenesis of an epithelium IMP
IMP: Inferred from mutant phenotype
10866680 MGI
involved in wound healing IMP
IMP: Inferred from mutant phenotype
10866680 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratin, type II cytoskeletal 6A

  • 60-kDa keratin

  • K6-alpha

  • cytokeratin-6A

  • keratin complex 2, basic, gene 6a

  • keratin complex 2, basic, gene 6c

  • keratin-6-alpha

  • mK6-alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07458 KRT6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Krt6a NCBI NCBI:3853