Lama1 - laminin, alpha 1 Gene

Also Known as Lama

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16772

Summary

Enables glycosphingolipid binding activity. An extracellular matrix structural constituent. Involved in protein phosphorylation. Acts upstream of or within several processes, including morphogenesis of an epithelium; neuron projection development; and retinal blood vessel morphogenesis. Located in basement membrane and cell-cell junction. Part of laminin-1 complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Orthologous to human LAMA1 (laminin subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Lama1 Products (1)

mRNA	Protein	Name
NM_008480.2	NP_032506.2	laminin subunit alpha-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables extracellular matrix structural constituent	IDA IDA: Inferred from direct assay	11984530	MGI
enables glycosphingolipid binding	IDA IDA: Inferred from direct assay	19118221	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8995276	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within branching involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	11798066	MGI
acts upstream of or within cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	11827968	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	1907584	MGI
acts upstream of or within establishment of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	15668394	MGI
acts upstream of or within morphogenesis of an epithelial sheet	IMP IMP: Inferred from mutant phenotype	11798066	MGI
acts upstream of or within neuron projection development	IDA IDA: Inferred from direct assay	19118221	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12885773	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	21052544	MGI
acts upstream of or within retinal blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	21052544	MGI
acts upstream of or within tissue development	IMP IMP: Inferred from mutant phenotype	15102706	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in basement membrane	IDA IDA: Inferred from direct assay	1292752	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	19319192	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	1907584	MGI
part of laminin complex	IDA IDA: Inferred from direct assay	8034675	MGI
part of laminin-1 complex	IDA IDA: Inferred from direct assay	9264260	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
laminin subunit alpha-1	S-LAM alpha S-laminin subunit alpha laminin A chain laminin-1 subunit alpha laminin-3 subunit alpha

Lama1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Lama1	P19137	DAG1	Bos taurus	O18738	Saturation Binding	16709410

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07497	LAMA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20976	Lama1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27493	Lama1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lama1	NCBI	NCBI:284217